Diffusion MRI Markers of Neural Reserve: Interaction Between Callosal Integrity and Clinical Vulnerability After Functional Neurosurgery in Parkinson’s Disease
Objective: To evaluate whether diffusion MRI markers of callosal integrity, together with baseline clinical vulnerability, are associated with cognitive trajectory after functional neurosurgical treatment in…Reducing Cost and Operative Time in DBS with a Consolidated Workflow: A Time-Driven Activity-Based Costing Analysis
Objective: To show that a consolidated patient specific workflow significantly improved operative efficiency and reduced personnel costs for deep brain stimulation (DBS) implantation, without compromise…Developing a Unified Advanced Neuromodulation Clinical Pathway for MR-Guided Focused Ultrasound and Deep Brain Stimulation
Objective: To analyze determinants of neuromodulation treatment selection, including patient preferences and clinical eligibility, in a large real-word cohort of patients diagnosed with Parkinson’s Disease (PD) and Essential…Outcomes of Bilateral Deep Brain Stimulation Following Prior MR-guided Focused Ultrasound Thalamotomy
Objective: To evaluate the safety and efficacy of subsequent Deep Brain Stimulation (DBS) as a management strategy for patients with recurrent or residual symptoms following MR-guided Focused Ultrasound (MRgFUS) thalamotomy. Background: Despite its…Evaluation of neurosurgical treatment outcomes for tremor using dynamics of tract density and total entropy of the dentatorubrothalamic tract
Objective: To evaluate the efficacy of stereotactic thalamotomy with tractography-based targeting of the dentatorubrothalamic tract (DRT) for tremor reduction in drug-refractory patients and to analyze…Unnecessary Ablative Surgery in an Untreated Parkinson’s Disease Patient: Marked Clinical Improvement After Initiation of Dopaminergic Therapy
Objective: To report a case of Parkinson’s disease (PD) in which two ablative procedures were performed without prior dopaminergic therapy, followed by significant clinical improvement…Functional neurosurgery in Parkinson’s disease: Effects on quality of life.
Objective: This study aims to determine the impact of surgical procedures on quality of life in patients with PD using the PDQ-39 questionnaire. Background: Parkinson's…Clinical Outcomes and Safety of Ablative Surgery for Parkinson’s Disease in Resource-Limited Settings: A Cohort from Indonesia
Objective: To evaluate the clinical outcomes and safety of ablative surgery for Parkinson’s disease at Indonesia’s national tertiary referral neurological center. Background: Deep brain stimulation…Challenging Traditional Paradigm: Clinical Outcomes of Early vs Late Subthalamic Deep Brain Stimulation in Parkinson’s Disease
Objective: Deep brain stimulation(DBS) of subthalamic nucleus(STN) is an established treatment for Parkinson’s disease(PD). DBS has been reserved for patients with long-standing disease and disabling…Neurofilament Light Chain Triggers Protein Aggregation, Neurotoxicity and Gliosis in Parkinson’s Disease through p38/MK2/NF-κB/CREB1 and Nrf2/HO-1 Signalling
Objective: This research investigated the active pathogenic property of Neurofilament light chain (NfL) in contributing to PD-like pathophysiology. We aimed to elucidate these mechanisms by…
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