Unnecessary Ablative Surgery in an Untreated Parkinson’s Disease Patient: Marked Clinical Improvement After Initiation of Dopaminergic Therapy
Objective: To report a case of Parkinson’s disease (PD) in which two ablative procedures were performed without prior dopaminergic therapy, followed by significant clinical improvement…Functional neurosurgery in Parkinson’s disease: Effects on quality of life.
Objective: This study aims to determine the impact of surgical procedures on quality of life in patients with PD using the PDQ-39 questionnaire. Background: Parkinson's…Clinical Outcomes and Safety of Ablative Surgery for Parkinson’s Disease in Resource-Limited Settings: A Cohort from Indonesia
Objective: To evaluate the clinical outcomes and safety of ablative surgery for Parkinson’s disease at Indonesia’s national tertiary referral neurological center. Background: Deep brain stimulation…Challenging Traditional Paradigm: Clinical Outcomes of Early vs Late Subthalamic Deep Brain Stimulation in Parkinson’s Disease
Objective: Deep brain stimulation(DBS) of subthalamic nucleus(STN) is an established treatment for Parkinson’s disease(PD). DBS has been reserved for patients with long-standing disease and disabling…Neurofilament Light Chain Triggers Protein Aggregation, Neurotoxicity and Gliosis in Parkinson’s Disease through p38/MK2/NF-κB/CREB1 and Nrf2/HO-1 Signalling
Objective: This research investigated the active pathogenic property of Neurofilament light chain (NfL) in contributing to PD-like pathophysiology. We aimed to elucidate these mechanisms by…PLIC Fractional Anisotropy and Motor Outcome After Functional Neurosurgical Treatment in Parkinson’s Disease
Objective: To assess whether microstructural integrity of the posterior limb of the internal capsule, measured by diffusion MRI fractional anisotropy, is associated with motor outcome…A Comprehensive Analysis of Advanced Deep Brain Stimulation Programming Strategies
Objective: To evaluate clinical rationale and outcomes of advanced deep brain stimulation (DBS) programming for movement disorders. Background: DBS is an effective treatment for medication…Diffusion MRI Markers of Neural Reserve: Interaction Between Callosal Integrity and Clinical Vulnerability After Functional Neurosurgery in Parkinson’s Disease
Objective: To evaluate whether diffusion MRI markers of callosal integrity, together with baseline clinical vulnerability, are associated with cognitive trajectory after functional neurosurgical treatment in…Reducing Cost and Operative Time in DBS with a Consolidated Workflow: A Time-Driven Activity-Based Costing Analysis
Objective: To show that a consolidated patient specific workflow significantly improved operative efficiency and reduced personnel costs for deep brain stimulation (DBS) implantation, without compromise…Developing a Unified Advanced Neuromodulation Clinical Pathway for MR-Guided Focused Ultrasound and Deep Brain Stimulation
Objective: To analyze determinants of neuromodulation treatment selection, including patient preferences and clinical eligibility, in a large real-word cohort of patients diagnosed with Parkinson’s Disease (PD) and Essential…
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