Caudal posterior substantia nigra iron increases longitudinally in Parkinson’s disease
Objective: To investigate spatial patterns and temporal evolution of substantia nigra (SN) iron accumulation in Parkinson’s disease (PD) using quantitative susceptibility mapping (QSM), an indirect…Evaluating Volume Changes in the Substantia Nigra Pars Compacta (SNc) in Parkinson’s Disease (PD) in a Study-Specific Magnetic Resonance Imaging (MRI) Template
Objective: To characterize the topography of SNc involvement in PD patients using neuromelanin (NM)-sensitive MRI (NM-MRI). Background: PD is characterized by the progressive loss of…Imaging biomarker for progression of motor symptoms in advanced Parkinson’s disease
Objective: The aim of the present study is to clarify correlation between motor deficits and dopaminergic neuronal loss in advanced Parkinson’s disease (PD). Background: Series…Changes in Neuromelanin MRI Signal in Parkinson’s Disease: A Longitudinal Study
Objective: To investigate the neuromelanin (NM) signal changes in Parkinson’s disease (PD) patients associated with disease progression. Background: PD is characterized by the progressive loss…The Use of Diffusion Weighted Imaging to Detect Structural Biomarkers in Recently-Diagnosed Parkinson’s Disease Patients
Objective: To quantify biomarkers for recently-diagnosed PD patients in the midbrain and their dopaminergic connections to the striatum. Background: The development of improved PD treatments…Correlation between substantia nigra measurement and UPDRS
Objective: Parkinson is mainly developed due to neurodegeneration of substantia nigra pars compacta (SNpc).the aim of our study was to check if there is any correlation between the size…Longitudinal Change of Substantia Nigra Hyperechogenicity in Parkinson’s Disease Cohort
Objective: To analyze whether the size of SN+ is differentially affected depending on disease duration. Secondly to analyze the interaction between a range of clinical…Targeted deep sequencing of brain DNA for detection of somatic point mutations in synucleinopathies
Objective: To detect relevant somatic "point mutations" (single nucleotide variants- SNVs) in brain-derived DNA in synucleinopathies. Background: There is increasing recognition that neurons may harbour…Sequencing of single human nigral dopaminergic neurons for somatic copy number variants
Objective: To detect somatic DNA copy number variants (CNVs) in dopaminergic neurons isolated from human substantia nigra, using shallow whole genome sequencing (WGS). Background: Somatic…Could curcumin be the preventive key of parkinson’s disease?
Objective: The present study evaluates the possible protective effect of curcumin on rats exposed to aluminum which is a major risk factor of parkinson's disease.…
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