Absence of wearing-off in Parkinson’s disease patients with treatment beyond 10 years
Objective: This study aims to explore the determinants for absence of wearing-off in patients with Parkinson’s disease (PD) based on a large cohort of Chinese…Cardiac sympathetic denervation can predict the wearing-off phenomenon in patients with Parkinson’s disease
Objective: To investigate whether cardiac sympathetic denervation increases the risk of the early wearing-off phenomenon in Parkinson's disease (PD). Background: Recent studies have suggested that…Efficacy of CVT-301 (levodopa inhalation powder) for treatment of OFF periods in Parkinson’s disease
Objective: Post-hoc analysis of subjects with Parkinson’s disease (PD) achieving > 30% reduction in UPDRS motor score (UPDRSIII) from pre- to post-dose over the first…Safinamide and Rasagiline effect on motor fluctuation, sleep quality and daytime sleepiness in Parkinson’s Disease: A validated questionnaires study
Objective: This is an observational study aimed at evaluating the effect of Safinamide and Rasagiline on motor fluctuations, subjective sleep and daytime sleepiness in Parkinson’s…Safety of sublingual apomorphine film (APL-130277) for the treatment of OFF episodes in patients with Parkinson’s disease: Results from a Phase 3 double-blind, placebo-controlled trial
Objective: To evaluate the safety of APL-130277 (APL) in the double-blind, placebo-controlled trial Titration Phase (TP) and Maintenance Phase (MP). Background: OFF episodes are a…Motor and non-motor symptoms of a 7.5-year prospective study of patients with Parkinson’s disease
Objective: Previously, we retrospectively reported the prevalence and risks of motor and non-motor symptoms of a large number of patients (1453) with Parkinson’s disease (PD)…Individualization of levodopa treatment using a microtablet dispenser and ambulatory accelerometry
Objective: This four-week open-label observational study describes the effect of introducing a microtablet dose dispenser and adjusting doses based on objective free-living motor symptom monitoring…Evaluation of non motor fluctuations in Parkinson disease by a visual analogue scale in Surgical Candidates
Objective: In Parkinson disease (PD) despite the high impact of nonmotor symptoms (NMSs) on patient autonomy and quality of life, evaluation of nonmotor fluctuations (NMF)…Translation and validation of the Filipino version of the wearing-off questionnaire-19 (F-WOQ-19)
Objective: This study aims to translate the Wearing-Off Questionnaire (WOQ) 19 into Filipino (F-WOQ-19) and validate the translated questionnaire. Background: Parkinson’s disease (PD) is a…Early morning OFF problems are common in PD patients attending a routine clinical appointment
Objective: To characterize early morning OFF problems in consecutive PD patients attending a routine clinical appointment. Background: In PD patients with motor fluctuations, total daily…
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