Session Information
Date: Wednesday, June 22, 2016
Session Title: Parkinson's disease: Neuroimaging and neurophysiology
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To investigate whether beta band activity (13-30Hz) and high-frequency oscillations (150-400Hz) arise from the same spatial location within the subthalamic nucleus (STN) of Parkinson’s disease patients.
Background: Parkinsonian bradykinesia and rigidity are typically associated with excessive beta band oscillations in the STN. Recently another spectral peak has been identified, within the 150-400Hz range, which is likely to be implicated in the disease. It expresses abnormally strong cross-frequency coupling with the beta band that correlates with bradykinesia/rigidity UPDRS scores [López-Azcárate et al., (2010) Neuroimage 30:6667; Van Wijk et al., submitted]. However, the neuronal origin of these high-frequency oscillations (HFO) and their contribution towards motor impairment remain to be established.
Methods: We recorded local field potentials through deep brain stimulation (DBS) electrodes implanted in the subthalamic nucleus. Recordings were done intra-operatively while advancing the leads in 2mm steps from 4mm above until 2mm below the surgical target point within the STN, resulting in 4 recording sites. Data from 28 nuclei in 16 patients were analysed. For each nucleus, we identified the recording site with the largest spectral peak in the beta band range, and the largest peak in the HFO range separately. In addition, we identified the recording site with the largest beta-HFO phase-amplitude coupling.
Results: Recording sites with largest beta band power and largest HFO power coincided in 54% of cases (chance expectation = 24%). Phase-amplitude coupling followed more closely the site with largest HFO (46%) than beta band power (39%).
Conclusions: HFO and beta band oscillations are likely to arise from spatially close neural populations. Further work is necessary to determine whether the different activities can help fine-tune DBS targeting.
To cite this abstract in AMA style:
B.C.M. van Wijk, A. Pogosyan, T. Foltynie, M.I. Hariz, P. Limousin, L. Zrinzo, P. Brown, V. Litvak. Intraoperative localization of beta band and high-frequency oscillations within the subthalamic nucleus [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/intraoperative-localization-of-beta-band-and-high-frequency-oscillations-within-the-subthalamic-nucleus/. Accessed June 15, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/intraoperative-localization-of-beta-band-and-high-frequency-oscillations-within-the-subthalamic-nucleus/