Session Information
Date: Thursday, June 8, 2017
Session Title: Parkinson’s Disease: Clinical Trials, Pharmacology And Treatment
Session Time: 1:15pm-2:45pm
Location: Exhibit Hall C
Objective: Comparing motor, cognitive, and psychiatric outcome 5 years after bilateral deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) and the subthalamic nucleus (STN) for advanced Parkinson’s disease (PD).
Background: Previous results from our clinical trial indicated better off-drug phase motor improvement after STN DBS 1 and 3 years after surgery (Odekerken et al., 2016). Additionally, we reported no relevant between-group differences on measures of cognitive and psychiatric functioning 3 years after surgery (Boel et al., 2016).
Methods: Patients were randomized to GPi DBS (n=65) or STN DBS (n=63). Standardized test assessment was performed at baseline, 1 year, 3 years, and 5 years. GPi and STN DBS were compared on UPDRS motor scores, MMSE, and HADS (Hospital Anxiety and Depression Scale) scores 5 years after surgery.
Results: A total of 71 patients completed (at least a part of) the 5-year follow-up, GPi DBS=33 and STN DBS=38. Drop-out rate was not significantly different between the groups (X2; p=0.28). The analyses on UPDRS, MMSE, and HADS scores are currently being performed.
Conclusions: The results of 5-year follow-up data will be presented at the congress.
References: V.J. Odekerken, J.A. Boel, B.A. Schmand, R.J. de Haan, M. Figee, P. van den Munckhof, P.R. Schuurman, R.M. de Bie, and the NSTAPS study group, GPi vs STN deep brain stimulation for Parkinson disease: Three-year follow-up, Neurology. 86 (2016) 755-761.
J.A. Boel, V.J. Odekerken, B.A. Schmand, G.J. Geurtsen, D.C. Cath, M. Figee, P. van den Munckhof, R.J. de Haan, P.R. Schuurman, R.M. de Bie, and the NSTAPS study group, Cognitive and psychiatric outcome 3 years after globus pallidus pars interna or subthalamic nucleus deep brain stimulation for Parkinson’s disease. Parkinsonism Relat Disord. 33 (2016) 90-95.
To cite this abstract in AMA style:
J. Boel, V. Odekerken, P. vanden Munckhof, G. Geurtsen, M. Figee, J. Dijk, R. de Haan, B. Schmand, P. Schuurman, R. de Bie. 5-year results from the NSTAPS trial: comparing bilateral deep brain stimulation of the globus pallidus pars interna versus the subthalamic nucleus for advanced Parkinson’s disease. [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/5-year-results-from-the-nstaps-trial-comparing-bilateral-deep-brain-stimulation-of-the-globus-pallidus-pars-interna-versus-the-subthalamic-nucleus-for-advanced-parkinsons-disease/. Accessed July 13, 2025.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/5-year-results-from-the-nstaps-trial-comparing-bilateral-deep-brain-stimulation-of-the-globus-pallidus-pars-interna-versus-the-subthalamic-nucleus-for-advanced-parkinsons-disease/