MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Early Adapter: Study Protocol for the Multi-Center Post-Market Study of Adaptive Deep Brain Stimulation (aDBS) in Japan

G. Oyama, A. Nakajima, H. Kamo, M. Nuermaimaiti, A. Bovet, J. Eubanks, H. Iwamuro, A. Umemura, N. Hattori, Y. Shimo (Tokyo, Japan)

Meeting: MDS Virtual Congress 2021

Abstract Number: 915

Keywords: Deep brain stimulation (DBS), Parkinsonism

Category: Parkinson's Disease: Neurophysiology

Objective: To assess the procedures for introducing two adaptive deep brain stimulation (aDBS) modes (single and dual threshold) in Parkinson’s disease patients (PD) in a real-world setting.

Background: DBS is an effective therapy for PD symptoms, though opportunities exist to improve the efficiency and efficacy. Conventional DBS is programmed to run continuously (cDBS). In contrast, aDBS may individualize and optimize PD therapy by adjusting stimulation based on brain activity measured as local field potentials (LFPs) through the same DBS electrodes. Both the aDBS algorithms and brain sensing technology used in this study are uniquely embedded in the DBS system. Although this implantable Neurostimulator is available worldwide, its aDBS algorithms are currently approved only in Japan.

Method: PD patients implanted with DBS leads either in the internal globus pallidus (GPi) or subthalamic nucleus (STN) connected to the DBS system. Both single and dual threshold aDBS modes use LFP oscillations in the Beta band (8-30 Hz) as control signals but differ with respect to their trigger points and stimulation parameters. Subjects will enter a 30-day Baseline Phase in their current cDBS programming configuration, followed by an aDBS Set-up and Adjustment Phase. The aDBS adjustment phases will involve measures of on time, quality of life, movement, patient preference, and satisfaction, all measured against the cDBS baseline. An Apple Watch will be used to provide a continuous, objective monitoring of key motor symptoms of PD (eg. tremor and dyskinesia).

Results: The primary endpoint is the acceptability of a mode, which is defined as greater than or equal to cDBS efficacy with minimal side effects according to the aDBS Global Impression of Change Score (GIC). Other endpoints will include output from the apple watch, the MDS UPDRS III, EQ-5D- 5L, PDQ-39, UDysRS, and patient preference. Safety will include evaluation of stimulation-related adverse events (AEs), other AEs, and device deficiencies.

Conclusion: This multi-center post-market study, which is the first to assess aDBS in a real-world clinical setting will test the safety, tolerability, and efficacy of two different aDBS modes.  Moreover, it may provide guidance for the broader use of aDBS and an early glimpse into efficacy compared to cDBS.

To cite this abstract in AMA style:

G. Oyama, A. Nakajima, H. Kamo, M. Nuermaimaiti, A. Bovet, J. Eubanks, H. Iwamuro, A. Umemura, N. Hattori, Y. Shimo. Early Adapter: Study Protocol for the Multi-Center Post-Market Study of Adaptive Deep Brain Stimulation (aDBS) in Japan [abstract]. Mov Disord. 2021; 36 (suppl 1). https://www.mdsabstracts.org/abstract/early-adapter-study-protocol-for-the-multi-center-post-market-study-of-adaptive-deep-brain-stimulation-adbs-in-japan/. Accessed May 21, 2025.
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to MDS Virtual Congress 2021

MDS Abstracts - https://www.mdsabstracts.org/abstract/early-adapter-study-protocol-for-the-multi-center-post-market-study-of-adaptive-deep-brain-stimulation-adbs-in-japan/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • An Apparent Cluster of Parkinson's Disease (PD) in a Golf Community
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • The hardest symptoms that bother patients with Parkinson's disease
  • What is the appropriate sleep position for Parkinson's disease patients with orthostatic hypotension in the morning?
  • Patients with Essential Tremor Live Longer than their Relatives
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • What is the appropriate sleep position for Parkinson's disease patients with orthostatic hypotension in the morning?
  • Welcome to the MDS Abstracts Site
  • An Apparent Cluster of Parkinson's Disease (PD) in a Golf Community
  • The hardest symptoms that bother patients with Parkinson's disease
  • Effect of marijuana on Essential Tremor: A case report
  • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • Estimation of the 2020 Global Population of Parkinson’s Disease (PD)
  • Patients with Essential Tremor Live Longer than their Relatives
  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
Wiley