Category: Parkinson's Disease: Neurophysiology
Objective: The aim of the study was to imply observer-independent approach to search for the ranges of stable oscillations in broad alpha-beta range inside the STN of patients with PD and to establish associations of isolated subbands with motor symptoms and DBS set-up.
Background: Beta oscillations in the STN contribute to pathophysiological mechanisms of PD, though frequency borders of beta subbands vary significantly across the studies. Only recently heterogeneity of beta rhythmic activity became the focus of research. Recently, alpha oscillations in the STN also has drawn an attention of researchers.
Method: LFP were recorded in the STN during DBS surgeries. Aperiodic component were extracted from the power spectra, and oscillating peaks in 8-35 Hz band with amplitudes exceeding 90% percentile were clustered into three sub-bands using Ward’s method. Clinical signs were assessed in patients with and without oscillation peaks in the lowest alpha-beta subband.
Results: Using hierarchical clustering, we separated alpha-beta (8-15 Hz), beta (15-25 Hz) and beta-gamma (25-35 Hz) subbands. Beta peaks were present in almost all inspected nuclei, alpha-beta peaks were found in about half of subjects, while beta-gamma peaks were rather sparse. Alpha-beta peaks were located more ventromedially compared to beta. Group of subjects with prominent alpha-beta peaks had higher disease duration, bradykinesia and rigidity scores compared to the group without alpha-beta peaks.
Conclusion: Splitting LFP spectra using clustering approach resulted in the subbands that shifted relative to conventional borders, and these oscillations differ not only in in their localization inside the STN but may also carry clinically relevant information about the degree of motor impairment along with PD progression. Therefore, increased alpha-beta oscillations may emerge as additional phenomena complementing beta oscillations; they may mark disease progression in PD and affect DBS stimulation setup. Work was funded by RScF (#22-15-00344).
To cite this abstract in AMA style:E. Belova, U. Semenova, A. Gamaleya, A. Tomskiy, A. Sedov. Emergent alpha-beta oscillations are accompanied with worsening motor symptoms in Parkinson’s disease [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/emergent-alpha-beta-oscillations-are-accompanied-with-worsening-motor-symptoms-in-parkinsons-disease/. Accessed September 23, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/emergent-alpha-beta-oscillations-are-accompanied-with-worsening-motor-symptoms-in-parkinsons-disease/