MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Evaluation of parkinsonism and striatal dopamine transporter loss in patients with spinocerebellar ataxia type 6

T. Xie, D. Appelbaum, J. Bernard, M. Padmanaban, Y. Pu, C. Gomez (Chicago, IL, USA)

Meeting: 2016 International Congress

Abstract Number: 1035

Keywords: Ataxia: Clinical features, Dopamine, Parkinsonism, Spinocerebellar ataxias(SCA)

Session Information

Date: Wednesday, June 22, 2016

Session Title: Ataxia

Session Time: 12:00pm-1:30pm

Location: Exhibit Hall located in Hall B, Level 2

Objective: To study whether spinocerebellar ataxia type 6 (SCA6) patients have parkinsonism and striatal dopamine transporter (DAT) loss compared to gender- and age-matched healthy controls.

Background: As the prototype for "pure cerebellar ataxia", SCA6 is generally considered to manifest solely with cerebellar dysfunction without parkinsonism. However, parkinsonism and striatal DAT loss have been reported in a few small studies albeit without gender– and age-matched healthy controls. Replicating those studies with more patients and well-matched controls would have important clinical impact.

Methods: Twelve patients with ataxia and genetically confirmed SCA6 (6 male and 6 female, age 65.3 ± 11.2 years, pathogenic CAG repeat number 21-25), and eight gender- and age- matched healthy controls (5 male and 3 female, age 71.3 ± 8.6 years) were assessed during 2013-2015 using Unified Parkinson’s disease Rating Scale (UPDRS), Scale of the Assessment and Rating of Ataxia (SARA), and DaTSCAN.

Results: There was generalized bradykinesia but without resting tremor or rigidity in SCA6 patients, which excluded parkinsonism. There was no DAT loss in putamen and caudate on DaTSCAN by visual inspection in a blinded manner independently by the nuclear medicine specialist and movement disorder specialist (kappa value=1). Further quantitative analysis on posterior, anterior and total putamen, and caudate did not reveal significant DAT loss in SCA6 patients compared to the gender- and age-matched controls.

Conclusions: There is no parkinsonism or significant DAT loss in SCA6 patients compared to gender- and age- matched healthy controls.

To cite this abstract in AMA style:

T. Xie, D. Appelbaum, J. Bernard, M. Padmanaban, Y. Pu, C. Gomez. Evaluation of parkinsonism and striatal dopamine transporter loss in patients with spinocerebellar ataxia type 6 [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/evaluation-of-parkinsonism-and-striatal-dopamine-transporter-loss-in-patients-with-spinocerebellar-ataxia-type-6/. Accessed May 15, 2025.
  • Tweet
  • Email
  • Print

« Back to 2016 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/evaluation-of-parkinsonism-and-striatal-dopamine-transporter-loss-in-patients-with-spinocerebellar-ataxia-type-6/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Yerba Mate (Ilex paraguaiensis) protects dopaminergic neurons degeneration and improve their maturation in culture
  • #26133 (not found)
  • Effect of marijuana on Essential Tremor: A case report
  • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • Estimation of the 2020 Global Population of Parkinson’s Disease (PD)
  • Patients with Essential Tremor Live Longer than their Relatives
  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
Wiley