MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Inferring the coupling of motor related brain areas during paced finger tapping in Parkinson’s patients

V. Seeger, F. Jung, L. Schneider, T.A. Dembek, P. Reker, N. Apetz, M. Tittgemeyer, L. Timmermann (Cologne, Germany)

Meeting: 2016 International Congress

Abstract Number: 1272

Keywords: Electroencephalogram(EEG), Motor control, Parkinsonism

Session Information

Date: Wednesday, June 22, 2016

Session Title: Parkinson's disease: Neuroimaging and neurophysiology

Session Time: 12:00pm-1:30pm

Location: Exhibit Hall located in Hall B, Level 2

Objective: To analyze the coupling and causal interplay of motor related brain areas in Parkinson’s patients during the performance of externally and internally paced finger tapping movements in comparison to age-matched healthy controls.

Background: Recent studies suggest that the development of cardinal motor symptoms like bradykinesia, rigidity and tremor are caused by the pathological coupling between motor brain areas and muscles.

Methods: We recorded an EEG with 128 „active“ electrodes together with an EMG of three forearm muscles in Parkinson’s patients (n = 12) and age-matched healthy controls (n= 12). Participants who were all right-handed performed a finger tapping task with the right index finger that consisted of four trials: 1) externally paced condition: the right index finger had to be moved up and down synchronously to an acoustic stimulus that was presented at 2 Hz, 2) internally paced condition: subjects had to reproduce the rhythm before heard, 3) a mixed condition in which ten stimuli were played and then stimuli were switched off while the subjects had to continue tapping and 4) a control condition in which the stimuli were presented, but participants were asked to sit still. Parkinson’s patients performed the behavioral task twice: After overnight withdrawal of the dopaminergic medication and after taking a standardized dose of L-Dopa. Data was analyzed with Dynamic causal modelling (DCM) for quasi stationary responses recorded electrophysiologically.

Results: PD patients performed worse than healthy controls independent of the tapping condition. Analyzing the amount of deviation from the demanded tapping frequency using a mixed design ANOVA, we found an effect of group (F (2.59, 41.50) = 3.30, p = 0.035) that reached statistical significance in the last third (400 s) of the experiment. Preliminary DCM-analysis reflected these differences.

Conclusions: Our results indicate, in line with other studies, the impairment of PD patients in generating and maintaining rhythmic movements, regardless of internal and external pacing. A preliminary connectivity analysis using a DCM of steady-state responses suggests differences in the coupling of motor brain areas between PD patients in the off and on state and healthy controls indicating pathological network connectivity. *Authors FJ and VS co-shared first authorship.

To cite this abstract in AMA style:

V. Seeger, F. Jung, L. Schneider, T.A. Dembek, P. Reker, N. Apetz, M. Tittgemeyer, L. Timmermann. Inferring the coupling of motor related brain areas during paced finger tapping in Parkinson’s patients [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/inferring-the-coupling-of-motor-related-brain-areas-during-paced-finger-tapping-in-parkinsons-patients/. Accessed May 15, 2025.
  • Tweet
  • Email
  • Print

« Back to 2016 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/inferring-the-coupling-of-motor-related-brain-areas-during-paced-finger-tapping-in-parkinsons-patients/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Yerba Mate (Ilex paraguaiensis) protects dopaminergic neurons degeneration and improve their maturation in culture
  • #26133 (not found)
  • Effect of marijuana on Essential Tremor: A case report
  • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • Estimation of the 2020 Global Population of Parkinson’s Disease (PD)
  • Patients with Essential Tremor Live Longer than their Relatives
  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
Wiley