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Multimodal neuroimaging of Parkinson’s disease with diffusion tensor imaging (DTI) and dopamine transporter (DAT) positron emission tomography

P. Honhar, S. Tinaz, M. Dias, R. Comley, S. Finnema, R. Carson, D. Scheinost, D. Matuskey (New Haven, USA)

Meeting: 2023 International Congress

Abstract Number: 1566

Keywords: Magnetic resonance imaging(MRI), Parkinson’s, Positron emission tomography(PET)

Category: Parkinson's Disease: Neuroimaging

Objective: The main aims of this study were to characterize brain microstructure alterations in a cross-sectional cohort of Parkinson’s disease (PD) with DTI and assess associations of DTI outcomes with DAT availability.

Background: 39 PD subjects without dementia [19F, age (mean±sd): 64±7y, MDS-UPDRS Part III:27±15, Hoehn-Yahr:2±0] and 22 healthy controls (HC) [14F, age:45±15y] underwent diffusion weighted imaging (b=2000 s/mm2, 64 directions, TR=4100ms, TE=88ms) on a 3T MR scanner. A sub-cohort of 24 subjects (15 PD, 9 HC) underwent dynamic DAT PET imaging on the HRRT with [18F]FE-PE2I.

Method: Diffusion images, corrected for susceptibility and eddy current distortions, were fit to a tensor model (FDT, FSLv6.0.1). Mean diffusivity (MD) and fractional anisotropy (FA) were assessed in white matter (WM) tracts through tract-based spatial statistics (TBSS), and in gray matter, by defining regions of interest on a standard template for the caudate, putamen and several cortical areas (Table 1). For the substantia nigra (SN), an in-house template based on previous PET studies was used. Kinetic modeling of dynamic PET data (SRTM, ref=cerebellum) was used to estimate DAT binding potential (BPND) in the SN, caudate and putamen. In addition to group differences, regional correlations with MDS-UPDRS Part III and associations between DAT BPND and DTI measures in the SN, caudate and putamen were evaluated in PD subjects.

Results: Significantly higher MD (no change in FA) was observed in multiple WM tracts in PD subjects in TBSS analyses (Fig1). Regionally, FA was elevated in the putamen (11%, p=0.01) and SN (7.4%, p=0.07) of PD subjects. MD was higher in several cortical areas (Table1), particularly in the parietal and occipital cortex, precentral and postcentral gyri (~10% each, p<0.01). DTI outcomes were not significantly associated with MDS-UPDRS Part III. DAT availability was significantly lower in the SN, caudate and putamen in PD (range: [33-66]% lower, p < 0.01, Table2) and BPND in the putamen was negatively associated with MDS-UPDRS Part III (r=-0.58,p=0.03). In PD subjects, DAT BPND in SN correlated negatively with FA in the putamen (r=-0.56,p=0.03,Fig2). DAT BPND was also negatively associated with MD (r=-0.67,p=0.01,Fig2) in the caudate.

Conclusion: Globally increased MD and higher FA in the putamen could be characteristic features of PD-induced microstructure alterations.

fig1

fig2

Table1

Table2

To cite this abstract in AMA style:

P. Honhar, S. Tinaz, M. Dias, R. Comley, S. Finnema, R. Carson, D. Scheinost, D. Matuskey. Multimodal neuroimaging of Parkinson’s disease with diffusion tensor imaging (DTI) and dopamine transporter (DAT) positron emission tomography [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/multimodal-neuroimaging-of-parkinsons-disease-with-diffusion-tensor-imaging-dti-and-dopamine-transporter-dat-positron-emission-tomography/. Accessed September 25, 2023.
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