Do Peripheral Inflammatory Markers Predict Impulse Control Disorders in Parkinson’s Disease? Insights from a Retrospective Study
Objective: To evaluate the relationship between hematological inflammatory markers—neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR)—and ICD development in PD patients treated with…Impact of Stigma on Patients Diagnosed with Parkinson’s Disease in Buenos Aires (Argentina) : A Descriptive Study of Psychological, Occupational, and Social Dimensions
Objective: To assess the characteristics and impact of stigma in Parkinson’s disease (PD)patients and explore differences by age, gender, education level, and disease duration. Background: Stigma…Patient-derived α-synuclein seed amplification as a tool for evaluating small molecule aggregation inhibitors for Parkinson’s disease and Lewy Body Dementia therapeutics
Objective: To validate on-target engagement of disease-relevant ⍺-synuclein (a-syn) aggregates by WTX-607, WaveBreak’s small-molecule clinical candidate for Parkinson’s disease (PD) and Lewy body dementia (LBD),…Interferon Therapy in Subacute Sclerosing Panencephalitis: An Underestimated Option?
Objective: To report the efficacy and safety of long-term intrathecal interferon therapy in a patient with SSPE. Background: Subacute Sclerosing Panencephalitis (SSPE), a fatal progressive…First-in-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Doses of ARV-102, a PROTAC LRRK2 Degrader, in Healthy Participants
Objective: To evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple ascending doses (SAD/MAD) of ARV-102, a PROteolysis TArgeting Chimera (PROTAC) leucine-rich…Lived Experiences in early clinical PD: Developing a Framework of a Novel Patient-reported Outcome (PRO) Fit-for-purpose for Disease Modification Therapeutic Trials
Objective: To characterize the lived experience of individuals at a prodromal stage of PD or with a recent clinical diagnosis. Background: There is no validated…Improving Guitar Strumming Mechanics in Parkinson’s Disease: A Case Series Using a Forearm Stabilization Device
Objective: This case series aims to explore the potential benefits of a guitar adaptation in enhancing mechanics of guitar strumming among this patient sample. Specifically,…Targeting IGF2 Signaling for Immune Modulation of Microglia in Parkinson’s Disease
Objective: We propose that IGF2 induces a distinct inflammatory phenotype in macrophages or microglia derived from Parkinson’s disease (PD) patients. Background: Microglia are the resident…Deep Learning-Driven Discovery of Mitochondrial Genomic Instability in Parkinson’s Disease: A Single-Cell Multi-Omics Approach
Objective: This study integrates snRNA-seq and proteomic data to (i) map mtDNA heteroplasmic mutations at single-cell resolution, (ii) identify mitochondrial-driven transcriptional dysregulation, and (iii) classify…Affordable Aspect of Artificial Intelligence Applied to Tremor’s Analysis Features Extraction Approach based on Archimede’s Spiral Processing
Objective: To use automated image analysis framework for tremor feature extraction from Archimedes spirals and analyse the findings based of the tremor’s type. Background: Defining…
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