Atrophy In Multiple System Atrophy Relates To Mitochondrial And Oligodendrocytic Processes
Objective: To investigate the gene expression and neurobiological underpinnings of brain atrophy in MSA using imaging transcriptomics and PET-based molecular annotation Background: The biological mechanisms…Association between Imaging Glymphatic Dysfunction Markers and Clinical Symptoms in Progressive Supranuclear Palsy
Objective: This study aims to explore possible glymphatic dysfunction using diffusion tensor image analysis along the perivascular space (DTI-ALPS) in patients with progressive supranuclear palsy…Frontal and Motor TMS Evoked Potentials Predict Response to Ventriculoperitoneal Shunt in NPH
Objective: Assess the ability of neurophysiological measure of TMS evoked potentials to predicts response to shunting in NPH. Background: NPH is an age-related condition of…A rapidly progressive multiple system atrophy-cerebellar variant model presentingα-synuclein oligomer spreading and phosphorylated α-synuclein aggregate formation accompanied with glial inflammation
Objective: We aimed to develop a rapidly progressive mouse model that recapitulates MSA-C pathology. Background: Multiple system atrophy (MSA) is a severe α-synucleinopathy driven by…Tracking Progression and Survival in a Large Cohort of Patients with Progressive Supranuclear Palsy
Objective: To characterise a longitudinal cohort of patients with Progressive Supranuclear Palsy (PSP) and identify factors influencing progression. Background: Median survival in PSP is approximately…Plasma tau-species-containing neuron-derived extracellular vesicles as potential biomarkers for progressive supranuclear palsy
Objective: This study aimed to develop and validate novel plasma PSP biomarkers based on tau-species-containing neuron-derived extracellular vesicles (NDEVs) in two independent cohorts (discovery and…LED Light as an Inductor of Optogenetic Activation of Astrocytes in Multiple System Atrophy
Objective: The pathogenesis of Multiple System Atrophy (MSA) involves the spread of misfolded α-synuclein from nerve cells to glia and dysfunction of mitochondria and proteasomes,…Underlying Diseases in a Patient with Upper Limb Clumsiness Suspected of Corticobasal Degeneration
Objective: This study aims to review the case of a patient with suspected corticobasal syndrome (CBS) who presented with upper limb clumsiness, and to discuss…PET and Clinical Evidence for Neuroprotective Effects of KM-819 on MSA
Objective: To assess the effect of KM-819 on the progression of multiple system atrophy (MSA). Background: Parkinson’s brain is associated with increased expression of the…Resolution Dependence of Machine Learning for Differential Diagnosis of Parkinsonian Eye Movements
Objective: To establish the extent to which high temporal resolution is required to differentiate between parkinsonian disease states from eye movements. Background: Previous studies have…
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