In silico predictive analytics: accelerating identification of potential disease-modifying compounds for Parkinson’s disease
Objective: To use an in silico screen to identify compounds that have potential to reduce α-synuclein (aSyn) oligomers and are amenable to drug repurposing for…Evaluation of Swallowing Function in Parkinson’s Disease Patients with and without Dysphagia Complaints
Objective: To assess swallowing functions of symptomatic and asymptomatic patients Parkinson's disease (PD). Background: Swallowing studies in PD without dysphagia symptoms are lacking and swallowing…Dural lymphatic vasculature in human superior saggital sinus: the brain drain
Objective: To provide independent validation in human dura obtained at autopsy of the reported presence of dural lymphatic vessels. Background: Two recent studies have challenged…Intracortical plasticity is preserved in de novo Parkinson’s disease: a tSMS study.
Objective: To test the intracortical plasticity of motor cortex in treatment-naïve (de novo) patients with Parkinson’s disease (PD), by means of transcranial static magnetic field…Salivary Alpha-Synuclein in Aging
Objective: We measured alpha-synuclein total (a-syntotal) and alpha-synuclein oligomers (a-synolig) concentration in 70 healthy subjects, of different ages (from 18 to 88 years old) to…Exposure to bifenthrin contributes to Parkinson’s disease in mouse model
Objective: To explore the relationship between pyrethroid bifenthrin and Parkinson’s disease on mouse model. Background: Pyrethroid is now widely used on account of its high…Detection of Early Changes in Microbiota Composition in Prodromal Parkinson’s Disease
Objective: To identify predictive markers of Parkinson’s disease (PD) in the gut microbiota composition of subjects at risk for developing PD due to a positive…Neuroprotective effect of α-Mangostin in restoration mitochondrial function in MPTP-Induced Parkinson’s disease in mice
Objective: The aim of the present study was to explore the protective effect of alpha-mangostin against mitochondrial oxidative stress in MPTP treated mice. Background: It…Efficient control of dopamine neuron physiology for rescuing disease phenotypes
Objective: Dopamine neurons (DAs) of the substantia nigra degenerate in Parkinson's disease and are disrupted in Huntington's disease. Here we propose single cell computational modeling…Quantifying postural stability differences in people with Parkinson’s disease with and without freezing of gait, using body-worn sensors
Objective: To quantify differences in postural responses to perturbations in people with Parkinson disease (PD) with and without freezing of gait (FOG+, FOG-, resp.), using…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.