Bidirectional gut-to-brain and brain-to-gut propagation of α-synuclein pathology in non-human primates
Objective: The prototypic synucleinopathy Parkinson's disease (PD) is hypothesized to spread out from the enteric nervous system (i.e. the gut) via the vagal nerve up…Relationship of Vitamin D deficiency with Parkinson’s disease risk
Objective: To study the level of vitamin D in the serum of Parkinson’s disease patients in the involvement of disease risk. Background: The Parkinson’s disease…Substantia nigra hyperechogenicity is similarly enlarged in Gaucher and in GBA mutation carriers
Objective: Testing the role of glycolipid accumulation in the risk for Parkinson's disease. Background: Increased risk for Parkinson's disease is well known among carriers of…Risk estimation in the years preceding diagnosis of Parkinson’s disease in the PREDICT-PD cohort
Objective: To test and refine the use of probability-based algorithms to identify individuals at high-risk of developing Parkinson’s disease (PD). Background: Neurodegeneration preceding a formal…Motivational effects on action selection and memory
Objective: Eye movements provide important insights into the pathophysiology of neurological disorders. Here two paradigms were devised to quantify effects of motivation on motor control…Levodopa-induced dyskinesia in Parkinson’s disease: Sleep matters
Objective: To investigate the relationship between slow wave activity (SWA) of non-rapid eye movement (NREM) sleep, which underlies adjustment of cortical excitability, and levodopa-induced dyskinesias…Influence of dopamine deficiency on interhemispheric crosstalk in Parkinson’s disease
Objective: To identify the significance of dopaminergic depletion in Parkinson’s disease (PD) on interhemispheric crosstalk using a complex bimanual tapping task. Background: Dopamine deficiency in…Profiles of microRNA in cerebrospinal fluid could be potential biomarkers for identifying motor subtype of Parkinson’s disease
Objective: We investigated CSF miRNA expression in PD and control subjects. We also evaluated if specific miRNA were differently expressed according to motor subtype of…Presence of Lewy dots in the brain of patients with Creutzfeldt-Jakob disease
Objective: We have investigated whether alpha-synuclein deposits exists in the brain of patients with Creutzfelt-Jakob disease Background: Creutzfeldt-Jakob’s disease (CJD) is a prion neurodegenerative disorder…No MPTP-induced behavioral deficits or Striatal field potential alterations in crossbreds of MPTP-susceptible and MPTP-resistant mice strains
Objective: To evaluate the electrophysiological and motor behavioural correlates of strain-dependent differential susceptibility of mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and the role of admixing thereon. Background:…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.