Repurposing Anti-Gout Medications for the Treatment of Parkinson’s Disease
Objective: To undertake a repurposing drug screen for Parkinson’s disease (PD) and further investigate the mechanism of action of top hits. To assess, in vivo,…iPLA2β controls ER-mitochondria tethering and Ca2+ transfer in Parkinson’s disease
Objective: In this study, we aimed to investigate whether Parkinson's disease (PD) associated calcium-independent phospholipase A2β (iPLA2β) regulates the integrity and functions of endoplasmic reticulum…Faecal Microbiota Transplant for Parkinson’s Disease: a Phase 1 Pilot Study to Establish Safety and Tolerability
Objective: We performed a pilot study looking at the safety and tolerability of Faecal Microbiota Transplantation, its effect on the microbiome, and improvement of symptoms…The Impact of VPS35 D620N Mutation on Alternative Autophagy and its Reversal by Estrogen in Parkinson’s Disease
Objective: We investigated the relationship between alternative autophagy and VPS35 D620N mutant-related PD pathogenesis. Background: VPS35 is critically involved in the mechanisms of neurodegeneration observed…Istradefylline therapy for dystonia in Parkinson’s disease
Objective: To clarify the basal ganglia network links between PD and Dystonia in PD (Dys-PD) co-occur, and to get the conceptually novel pharmacotherapy. Background: Dys-PD is one…ECAP-Controlled Closed-Loop SCS Alleviates Neuropathic Pain and Improves Motor Function in a Patient Suffering from Parkinson’s Disease and Radicular Pain
Objective: The objective of this case report is to highlight the effect of a new technology, Evoked Compound Action Potential (ECAP) controlled closed-loop spinal cord…Interaction of GCase and ganglioside GM1 in the aggregation of α-Synuclein
Objective: The objective of this work is to investigate the relationship between ganglioside GM1 levels and α-synuclein aggregation in the context of GBA1 mutations. Background:…Efficacy of Audiovisual Neuromodulation in the Treatment of Parkinson’s Disease
Objective: To evaluate the AVS effectiveness in depression, anxiety, autonomic disorders and visual dysfunction in PD patients. Background: The severity of non-motor dopa-resistant symptoms in…Deep Brain Stimulation of the Subthalamic Nuclei in Advanced Parkinson’s Disease what Effects on Motor Non-motor and Neuropsychological Functions a Monocentric Prospective Study with a 12-month Follow-up
Objective: The aim of the study is to assess the evolution of motor symptoms (MS), non-motor symptoms (NMS) and neuropsychological functions (NF) in Parkinson's disease…Simulated Space Gravity Recapitulates Parkinson’s Disease Pathology in Neural Cell Model
Objective: This investigation centers on the potential influence of microgravity on α-synuclein aggregation, a hallmark feature of Parkinson's disease (PD) characterized by the formation of…
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