Disease severity is not predictive of the dose required for apomorphine sublingual film (APL-130277) to convert a patient with Parkinson’s disease from OFF to fully ON
Objective: Evaluate whether baseline disease severity is predictive of the effective APL-130277 dose to turn a patient with Parkinson's disease (PD) from OFF to fully…Treatment of OFF episodes in Parkinson’s disease: An evaluation of patient and caregiver insights
Objective: Evaluate patient and caregiver opinions into the treatment of OFF episodes in patients with Parkinson's disease (PD). Background: OFF episodes are fairly common in…Treatment of OFF episodes in Parkinson’s disease: An evaluation of physician practices
Objective: Determine physician practices into the treatment of OFF episodes in patients with Parkinson's disease PD. Background: OFF episodes are fairly common in patients with…Enteric neurons reveal substantial in vivo mitochondrial changes in Parkinson’s disease
Objective: Study in vivo mitochondrial and ganglionic morphometrics of enteric neurons in Parkinson's disease. Background: While well established in autopsy studies, the crucial role of…Detection of leucine-rich repeat kinase 2 in human biofluids
Objective: To evaluate the presence of leucine-rich repeat kinase 2 (LRRK2) in human biosamples, including cerebrospinal fluid (CSF) and urine, as a first step towards…The small GTP-binding protein Rhes influences midbrain dopaminergic neurons: Behavioral and biochemical studies
Objective: Rhes is a small GTP-binding protein highly enriched in the striatum, developmentally regulated by thyroid hormone, and by dopamine (DA) innervation in adult rat…Histone deacetylase 4 is regulated by microRNA 128 in SH-SY5Y cells of Parkinson’s disease
Objective: To explore the mechanisms and regulating effects of microRNA 128 in Parkinson's disease (PD). Background: PD is the second common progressive neurodegenerative disorder characterized…Disruption of circadian rhythm function and anti-oxidation via SIRT1-BMAL1 pathway in 6-OHDA induced Parkinson’s disease model
Objective: Our aim is to investigate whether the altered expression of clock genes is associated with the dysfunction of the anti-oxidative ability in Parkinson's disease.…Evaluation of the role of oxidative stress in Parkinson’s disease and Parkinson plus syndrome
Objective: To evaluate the role of oxidative stress in peripheral blood in patients with Parkinson's disease (PD) and Parkinson plus syndrome (PPS). Background: Slight excess…Oral apomorphine film (APL-130277) produces no buccal mucosal irritation: Results of a toxicological study
Objective: Determine the tolerance of and potential for cheek pouch buccal mucosa irritation following the administration of apomorphine film (APL-130277). Background: APL-130277 is a sublingual…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.