Increased cellular co-localization of tau fragment 1-368 and alpha-synuclein in two mouse model of Parkinson’s disease
Objective: To examine the distribution of a novel tau pathology and its interaction with alpha-synuclein in two mouse model of Parkinson's disease (PD). Background: Cleavage…Longitudinal cerebrospinal fluid biomarkers in early Parkinson’s disease and healthy controls
Objective: To analyze changes in levels of four distinct biomarkers in drug-naïve Parkinson's disease (PD) subjects in cerebrospinal fluid (CSF) over 6- and 12 mo…Apocyanin ameliorates post-stroke movement disorder in rats: Possible role of neurochemical and inflammatory alterations
Objective: To study the neuroprotective efficacy of apocynin, a NADPH oxidase inhibitor in 1) alterations of post- stroke motor behaviour, 2) alterations of various neurotransmitter…ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways
Objective: Endosomal sorting required for transport (ESCRT) orchestrates endo-lysosomal soring of ubiquitinated proteins, multivesicular body formation. The aim of this study is to elucidate the…Altered glutamate response and calcium dynamics in iPSC derived striatal neurons from XDP-patients
Objective: Our objective was to generate an in vitro model of XDP based on striatal neurons differentiated from induced pluripotent stem cells (iPSC), followed by…Relative hypoglycemia induces acute chorea followed by chronic parkinsonism in a diabetic patient on hemodialysis: A case with sequential clinico-radiological correlate
Objective: To present a sequential clinico-radiological study of a diabetic patient on hemodialysis who developed acute chorea followed by chronic parkinsonism. Background: Hyperglycemic chorea is…Induced pluripotent stem cell-derived cortical neurons as a disease model for X-linked dystonia-parkinsonism
Objective: To elucidate the disease-associated cellular phenotype of induced pluripotent stem cell (iPSC)-derived cortical neurons of patients affected by X-linked dystonia-parkinsonism (XDP). Background: XDP is…Phosphorylation by GSK-3β enhances binding of metal ion induced tau oligomers to neutral lipid surfaces
Objective: To dissect the complex interplay of tau hyperphosphorylation, metal ion induced oligomer formation and membrane interactions applying single particle fluorescence techniques. Background: Fibrillar deposits…Propranolol therapy for tardive dyskinesia: A retrospective examination
Objective: To examine the tolerability and effectiveness of propranolol in treating tardive dyskinesia (TD). Background: TD is a disabling, often irreversible, movement disorder that results…1 to 40 years later: Delayed effects of brain radiation presenting as parkinsonism
Objective: To report 3 adult cases of delayed radiation induced parkinsonism, with latency ranging from 1 to 40 years. . Background: Unequivocal radiation induced parkinsonism…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.