Detection of Early Changes in Microbiota Composition in Prodromal Parkinson’s Disease
Objective: To identify predictive markers of Parkinson’s disease (PD) in the gut microbiota composition of subjects at risk for developing PD due to a positive…Neuroprotective effect of α-Mangostin in restoration mitochondrial function in MPTP-Induced Parkinson’s disease in mice
Objective: The aim of the present study was to explore the protective effect of alpha-mangostin against mitochondrial oxidative stress in MPTP treated mice. Background: It…Efficient control of dopamine neuron physiology for rescuing disease phenotypes
Objective: Dopamine neurons (DAs) of the substantia nigra degenerate in Parkinson's disease and are disrupted in Huntington's disease. Here we propose single cell computational modeling…Quantifying postural stability differences in people with Parkinson’s disease with and without freezing of gait, using body-worn sensors
Objective: To quantify differences in postural responses to perturbations in people with Parkinson disease (PD) with and without freezing of gait (FOG+, FOG-, resp.), using…Eight contact LFP recordings in the Subthalamic region localize beta source to the dorsal STN
Objective: The aim of this study was to investigate the electrophysiological characteristics of intra and extra STN LFPs in PD to better locate the source…Phosphodiesterases and striatal pathways in Parkinson’s disease
Objective: To use phosphodiesterase (PDE)10A ([11C]IMA107) and PDE4 ([11C]Rolipram) positron emission tomography (PET) molecular imaging combined with diffusion tensor imaging (DTI) based probabilistic tractography to explore the expression…Objective gait parameters as a noninvasive biomarker for freezing of gait in Parkinson’s disease patients
Objective: To determine if steady-state gait parameters in Parkinson disease (PD) patients could serve as a predictive biomarker for freezing of gait (FOG). Background: FOG…Increased appendicular lean body mass is associated with increased cerebral cholinergic innervation in Parkinson disease
Objective: The main aim of this study was to examine the effect of cholinergic nerve terminal integrity in the brain on measures of sarcopenia. Background:…Optimization of Synucleinopathy and Nigrostriatal Degeneration Induced by Injection of Alpha-Synuclein Preformed Fibrils into Rat Striatum
Objective: Optimization of the surgical parameters (intrastriatal placement and concentration of alpha-synuclein preformed fibrils; α-syn PFFs) to increase the magnitude of nigrostriatal α-syn pathology and…Genetic knock-down of HDAC4 attenuates rotenone-induced abnormal expression of α-synuclein by affecting autophagic flux in SH-SY5Y Cells
Objective: To assess whether histone deacetylase 4 (HDAC4) is related to the abnormal expression of α-synuclein (α-syn) via the autophagy pathway. Background: The overexpression and…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.