Refining and Understanding Causal Relationships between Brain Imaging-Derived Phenotypes and Parkinson’s Disease: a Bidirectional Mendelian Randomization Study and Clinical Validation
Objective: Utilizing bidirectional two-sample Mendelian randomization, we explored the causal associations between imaging-derived phenotypes (IDPs) and Parkinson's Disease (PD), along with its manifestations. Background: Observational…Longitudinal Structural and Functional Correlates of Progression in Isolated Rapid Eye Movement Sleep Behaviour Disorder
Objective: To identify progressive structural and functional imaging alterations in a longitudinal cohort of patients with isolated rapid eye movement sleep behavior disorder (iRBD). Background:…First in vivo evidence of the role of the noradrenergic system in olfactory dysfunction in Parkinson’s disease
Objective: To investigate the relationship between in vivo noradrenergic markers and olfactory impairment in patients with Parkinson’s disease (PD). Background: Degeneration of the noradrenergic (NA)…Enlarged Perivascular Spaces in the Temporal Lobe as a Predictor for Incident Dementia in Parkinson’s Disease
Objective: To evaluate the whether regional burden of enlarged perivascular space (EPVS) hold prognostic value in predicting the dementia conversion in Parkinson's disease (PD). Background:…Evaluating Fall Risk in People with Parkinson’s Disease Using a Novel Comprehensive Posturography Assessment
Objective: To determine if a comprehensive balance assessment on a posturography system can identify retrospective Fallers from Non-fallers in people with Parkinson’s disease (PwPD). We…Effects of striatal dopamine depletion and altered brain metabolism on Parkinson’s disease
Objective: To investigate the relationship between striatal dopamine depletion, altered brain metabolism, motor deficits, and cognitive dysfunction in Parkinson’s disease (PD) Background: PD shows degeneration…Automated Imaging Differentiation of Parkinsonism (AIDP): A Prospective 21-site Trial within the Parkinson’s Study Group
Objective: To prospectively test the performance of Automated Imaging Differentiation of Parkinsonism (AIDP), a machine learning based diagnostic biomarker software for Parkinson’s disease (PD), multiple system atrophy Parkinsonian…Clinical and Brain Morphological Characteristics of Early LRRK2-associated Parkinson Disease
Objective: To investigate the impact of LRRK2 mutation in Parkinson disease (PD) and to explore the preclinical markers of LRRK2 mutation carriers who will develop…MIBG Uptake in the Major Salivary Glands in Patients with Parkinson’s Disease and Dementia with Lewy Bodies
Objective: The aim of the study was to compare the metaiodobenzylguanidine (MIBG) uptake in the major salivary glands (MSG) in patients with Parkinson’s disease (PD)…Characterising early morning akinesia and off (EMO) using Parkinson’s kinetigraph: analysis from a two centre national database in Parkinson’s disease .
Objective: Could wearable sensors such as Parkinson’s kinetograph (PKG) may provide valuable overnight data to detect EMO to augment care in clinic. Background: Early morning…
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