The epigenetic regulation of HIF-1α by SIRT1 in MPP+ treated SH-SY5Y cells
Objective: Both silent information regulator 1 (SIRT1) and hypoxia inducible factor 1 (HIF-1) have been found to play important roles in the pathophysiology of Parkinson's…Generation of dopaminergic neurons for studying Parkinson’s disease using patient blood cells
Objective: To study the molecular mechanism of G2385R mutation of LRRK2 gene in PD developing, dopaminergic neurons are derived from patient specific induced pluripotent stem…Is the assessment of 5 meters of gait with body-worn-sensors enough to recognize Parkinsonian gait?
Objective: To classify step-by-step gait patterns of Parkinson's disease (PD) patients and older adults from the assessment of short episodes of gait with body-worn-sensors (BFS)…Long-duration response to levodopa in Parkinson’s disease is independent of disease duration: A prospective study on de novo patients in Ghana
Objective: To prospectively investigate the response to acute levodopa challenge in patients with advanced Parkinson's disease (PD) never treated before. Background: Pathophysiological mechanisms underlying motor…Mitochondrial response precedes intracellular accumulation of α-synuclein in Parkinson’s disease
Objective: To investigate the expression of mitochondrial COX-IV during the progression of Parkinson's disease. Background: Parkinson's disease (PD) is a neurodegenerative disease characterized by the…Chronic cerebral hypoperfusion accelerates cognitive dysfunction and microvascular impairment in the MPTP mouse model of Parkinson’s disease
Objective: To evaluate cerebral hypoperfusion on cognitive dysfunction and related microvascular impairment in the MPTP mouse model. Background: Vascular pathology and Parkinson's disease (PD) pathology…Lessons learned from the Nilotinib trial: Cardio-vascular conditions in parkinsonism
Objective: A retrospective records review of 9 patients that failed screening for a clinical trial was performed to examine the co-morbid cardiac manifestations of PD…Modulating neuronal activity in dopaminergic neurons to promote their survival
Objective: To manipulate the activity of dopaminergic (DA) neurons in culture using pharmacological and molecular tools to promote their survival. Background: Parkinson's disease is a…Constipation in early de novo Parkinson’s disease: Prevalence and correlates with clinical features, imaging and non-imaging biomarkers
Objective: To explore the association between constipation and clinical features, imaging and non-imaging biomarkers in early de novo (untreated) Parkinson's disease (PD) patients. Background: Constipation…A novel C. elegans model for identification of small molecules that target alpha-synuclein-mediated toxicity
Objective: To develop a novel transgenic C. elegans model to study dopaminergic neurodegeneration mediated by alpha-synuclein. Background: Targeting alpha-synuclein could be a disease-modifying strategy for…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.