Investigating the role of NLRP3 Inflammasome as Biomarkers and Therapeutic Targets in Parkinson’s Disease Pathogenesis
Objective: To elucidate the role of NLRP3 Inflammasome in PD pathogenesis and its role in differential susceptibility. Background: Inflammasomes play a role in the progression…Profile and Predictors of Depression in Parkinson’s Disease Patients attending the Neurology Clinic at the University College Hospital, Ibadan, Nigeria.
Objective: My aim is to investigate the frequency, profile, and predictors of depression in PD patients compared to age- and gender-matched controls using the Hamilton…Developing Disease-duration Specific Percentiles for Prospective Subtyping of the Diffuse Malignant Parkinson’s Disease: A PPMI-based study
Objective: To enable prospective identification of individuals with diffuse malignant (DM) Parkinson’s disease (PD) by establishing disease-duration-specific thresholds for motor and non-motor symptom scales. Background:…A multi-center, randomized, controlled study of the add-on effect of selegiline or zonisamide to L-dopa/DCI therapy in Parkinson’s disease (DATSZ-PD study)
Objective: To investigate the efficacy and safety for neuroprotection and disease modifying effect in selegiline(SL) or zonisamide(ZN) by using UPDRS, PDQ-39 and DAT -SPECT in…Rescuing alpha-synuclein toxicity through neuron-specific enhancement of autophagy
Objective: In the present study, we aim to counteract regulatory and transcriptional modifiers of autophagy to enhance neuroprotective proteostasis and rescue alpha-synuclein (asyn) toxicity in…χ-DBS: An Open-Source Susceptibility Atlas Tool for Deep Brain Stimulation Target Visualization and Segmentation
Objective: This work is motivated by the need for atlas creation tools for susceptibility maps presurgically acquired for deep brain stimulation (DBS). Segmentations aid in…Modeling Inflammation in GBA-Associated Parkinson’s Disease: Insights into Disease Mechanisms
Objective: This investigation centers on the role of inflammation in GBA-associated Parkinson’s disease (PD), a neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons,…Utilising Beta Power in Local Networks to Predict Freezing of Gait Events in Parkinson’s Disease
Objective: Our study examined brain network changes during the transition to Freezing of Gait (FOG) versus voluntary stopping. Identifying specific neural alterations may help establish…Fatty Acid Metabolic Reprogramming Regulates Glial-Epithelial Axis via Nur77 Palmitoylation in Intestinal Dysfunction in Parkinson’s Disease
Objective: This study aims to elucidate the regulatory role of stearoyl-CoA desaturase 1 (SCD1) in Parkinson’s disease (PD)-associated intestinal dysfunction, focusing on its mechanism in…Metabolomic Profiling in an Egyptian Cohort Reveals Altered Phenylalanine Metabolism and Suggests a Role for Trans-Cinnamate in Parkinson Disease
Objective: Investigate the associated metabolic changes in PD via a comprehensive metabolic analysis with a focus on phenylalanine (dopamine precursor) metabolism and its impact on…
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