Disparities in Accessing MRI-Guided Focused Ultrasound (MRgFUS) and Gamma Knife for Tremor Treatment: A Retrospective Chart Review
Objective: Quantitatively describe demographic disparities among patients with tremor treated with MRgFUS and GK. Background: Thalamotomy is an established and effective treatment of tremor when…Mutation screening of Miro1 and Miro2 in Parkinson’s disease
Objective: We aimed to systematically evaluate the genetic associations of Miro1 and Miro2 with PD in a large Chinese cohort. Background: Miro1 has been identified to be a novel causative gene…Trancranial Sonography Reveals Striatal Neurodegeneration in the Prodromal Phase of X-linked Dystonia-Parkinsonism
Objective: To use transcranial sonography (TCS) to detect striatal and substantia nigra abnormalities in patients with X-linked dystonia-parkinsonism syndrome (XDP), non-manifesting carriers (NMC) of the…Associations Between FDG-PET Regional Metabolism and Clinical Severity in Progressive Supranuclear Palsy
Objective: To characterize the clinical profile, disease progression, and their associations with neuroimaging biomarkers in patients with Progressive Supranuclear Palsy (PSP). Background: PSP encompasses a…The Landscape of Movement Disorders in Mitochondrial Aminoacyl t-RNA Synthetase Disorders: A Case Series
Objective: To characterize the movement disorder spectrum in mitochondrial aminoacyl-tRNA synthetase (m-aaRS)defects. Background: m-aaRS disorders are an increasingly recognized genetic conditions demonstrating marked phenotypic pleiotropy,…Interpretable AI for Quantitative Video-Based UPDRS Assessment of Hand Movements in Parkinson’s Disease
Objective: To quantify and compare the diagnostic contributions of the three standard MDS-UPDRS hand motor tasks using video-based assessment of bradykinesia in Parkinson's Disease (PD).…Stereotactic Neurosurgery for Holmes Tremor: a Retrospective Cohort Study
Objective: To evaluate the efficacy of stereotactic neurosurgery for Holmes tremor in a consecutive cohort and identify predictors of treatment outcome. Background: Holmes tremor is…Sex Differences in Prodromal Features of Parkinson’s Disease: Evidence from Large Multi-Centre Cohorts
Objective: To explore sex differences in symptoms of prodromal Parkinson’s disease (PD) in large, population-based multi-centre cohorts of healthy individuals, PREDICT-PD and Healthy Brain Ageing…Feasibility of home-based assessments using wearable sensors and videos in children with GNAO1-related movement disorders: A pilot study
Objective: To investigate feasibility of home-based assessments in GNAO1-related dystonia, using wearable sensors and home-videos. Background: Movement disorders in GNAO1-associated disorder are common, with dystonia…Cerebellar α-Synucleinopathy Contributes to Gait and Balance Impairment in Parkinson’s Disease
Objective: To determine whether cerebellar α-synuclein (α-syn) pathology contributes to the onset and progression of postural instability and gait difficulty (PIGD)-like motor deficits in Parkinson’s…
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