White Matter Hyperintensity and the Spatial Subtypes in Parkinson’s Disease
Objective: To determine whether white matter hyperintensity (WMH) volume and its spatial subtypes, periventricular WMH (PWMH) and deep WMH (DWMH), are associated with cognitive impairment…Sex Differences in Prodromal Features of Parkinson’s Disease: Evidence from Large Multi-Centre Cohorts
Objective: To explore sex differences in symptoms of prodromal Parkinson’s disease (PD) in large, population-based multi-centre cohorts of healthy individuals, PREDICT-PD and Healthy Brain Ageing…Disease Endophenotyping through Graph and Adjacency Metrics (DEGAS): Network Biomarkers for Parkinson’s Disease Prognosis
Objective: To develop a machine learning framework using resting-state functional connectivity to identify neural signatures of Parkinson's disease (PD) and forecast disease progression. Background: PD…Chinese Expert Consensus and Recommendations on Sensing-guided Deep Brain Stimulation for Parkinson’s Disease: A Modified Delphi Study
Objective: To propose some well-accepted recommendations on sensing-guided deep brain stimulation for Parkinson's Disease. Background: Deep brain stimulation (DBS) has been widely accepted as a well-established neurosurgical…Distinct Cognitive Profiles in Parkinson’s and Alzheimer’s Disease: Evidence from a Large Neurodegenerative Cohort
Objective: To compare cognitive profiles across patients with Parkinson’s disease and Alzheimer’s disease using standardized neuropsychological assessment. Background: Cognitive impairment is a major feature of…Evaluation of Polygenic Risk Scores Derived from an Updated Cross-European GWAS for Parkinson’s Disease Prediction in European and Ashkenazi Jewish Populations
Objective: To evaluate whether polygenic risk scores (PRS) derived from a recent genome-wide association study (GWAS) improve Parkinson’s disease (PD) prediction compared with PRS derived…Nigrostriatal Dopaminergic Patterns in Dementia with Lewy Bodies and Parkinson’s Disease Subtypes: A DAT-SPECT Study within the SOC Framework
Objective: To determine whether the pattern of nigrostriatal dopaminergic degeneration in DLB mirrors that of “body-first” PD using DAT-SPECT imaging. Background: Dementia with Lewy bodies…Understanding the Impact of the Small Scale Levodopa-Entacapone-Carbidopa-Intestinal-Gel Pump on Everyday Experiences of People Living with Parkinson’s Disease: A Mixed-Methods Evaluation
Objective: This study aims to qualitatively evaluate the impact of switching from the conventional Levodopa-Carbidopa-Intestinal-Gel (LCIG) pump to the smaller sized Levodopa-Entacapone-Carbidopa-Intestinal-Gel (LECIG) pump on…L-DOPA Metabolism as a Function Related to the Potency of iPSC-Derived Dopaminergic Progenitor cells
Objective: This study aimed to elucidate how iPSC-derived dopaminergic progenitor cells (iPSC-DAPs) acquire the ability to metabolize L‑DOPA in vitro and to evaluate whether the…Phase 2 Trial for the Treatment of Early-stage Parkinson’s Disease with TJ0113, a Small Molecule Mitophagy Activator
Objective: To investigate the efficacy and safety of TJ0113 for patients with early-stage Parkinson's disease. Background: Mitochondrial dysfunction, particularly decreased mitophagy, may contribute to the pathogenesis of…
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