Identification of Distinctive Iron Deposition Pattern in Subcortical Nuclei of Parkinson’s Disease using Radiomics: A 7T Susceptibility-Weighted Imaging Study
Objective: To develop the optimal radiomics signature of distinctive subcortical nuclei iron deposition pattern for diagnosis and differential diagnosis of Parkinson’s disease (PD) at 7T susceptibility-weighted imaging (SWI).…Early Impairment in the Immunomodulatory Function of Mesenchymal Stromal Cells Contributes to Heightened Peripheral and Neuroinflammation in Parkinson’s Disease Insights From In Vivo Chronic PD Rat Model and In Vitro PD iPSC Model
Objective: To assess the timeline dependent changes in endogenous Bone-Marrow-Mesenchymal-Stromal-Cells (BMMSC) in in-vivo chronic PD model and validating these cellular modifications in human iPSC derived…Effect of Aβ on α-synuclein propagation
Objective: To investigate how amyloid-beta (Aβ) pathology affects α-synuclein (α-syn) propagation. Background: Lewy bodies, the pathological hallmark of Parkinson’s disease and dementia with Lewy bodies,…Continuous Subcutaneous Dopaminergic Stimulation: Exploring the impact of Foslevodopa/Foscarbidopa on Gait in Parkinson’s disease.
Objective: The primary objective of this study is to investigate the effect of continuous subcutaneous infusion (CSCI) of foslevodopa/foscarbidopa (FL/FC) on gait in those with…Patient-specific Vascularized Midbrain Assembloids with Microglia show Altered Neuroinflammatory Phenotypes in Parkinson’s Disease
Objective: This study aims to develop patient-specific vascularized midbrain assembloids incorporating microglia to better model the neuroinflammatory environment of Parkinson’s disease (PD). By integrating vascular…Longitudinal MRI Study of Hippocampal Subfields Morphometry in Early Parkinson’s Disease
Objective: This prospective cohort study longitudinally investigated hippocampal subfield shape deformation and atrophy in early-stage Parkinson’s Disease (PD), using spherical harmonic-based shape analysis. Background: Hippocampal…Neuroprotective Effects of ATP6V0C Overexpression in PFF Model Mice
Objective: Elucidating the role of lysosomal dysfunction due to altered stability and expression levels of V-type proton subunit ATP6V0C in the degradation and propagation of…Complement C4 Exacerbates Inflammation and Neuronal Damage in Vivo
Objective: To investigate the specific effects of the core complement component C4 on α-synuclein aggregation and neuroinflammation during the pathogenesis of PD. Background: Synucleinopathies are…Patient And Clinician Perceptions Of Disease Improvement With Levodopa–Entacapone–Carbidopa Intestinal Gel (LECIG) In Advanced Parkinson’s – Data From The ELEGANCE Interim Analysis
Objective: To evaluate clinicians’ and patients’ views of the level of improvement in Parkinson’s disease (PD) achieved following up to two years of treatment with…Subthalamic versus Pallidal Temporal Interference Stimulation in Parkinson’s Disease: A Pilot Study
Objective: To investigate whether transcranial temporal interference stimulation (tTIS) targeting different deep brain regions produces symptom-specific improvements consistent with established deep brain stimulation (DBS) outcomes…
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