String Vessel Formation Regionally Increases in Long Duration Parkinson’s Disease
Objective: Parkinson's disease is a movement disorder characterised by α-synuclein deposition in the form of Lewy bodies and Lewy neurites. Vascular changes have been thought to contribute…Unsupervised Learning Approach for Pathology-Based Subtyping and Staging Multiple System Atrophy
Objective: To develop a classification and staging system for multiple system atrophy (MSA) using data-driven disease progression modeling. Background: MSA exhibits varying degrees of degeneration…Catalan MSA Registry (CMSAR): Applying new Clinical Criteria and Biomarkers for Increasing Diagnostic Accuracy, is New Better?
Objective: To reassess the CMSAR and determine if new criteria and new biomarkers can enhance diagnostic accuracy. Background: The CMSAR, conducted between 2015 and 2019,…Clinical and neuroimaging factors associated with survival in Multiple System Atrophy
Objective: To assess clinical and neuroimaging factors associated with survival in a cohort of patients with a final clinical diagnosis of Multiple System Atrophy (MSA)…Pharmacokinetics And Safety Of YA-101, A Dual Inhibitors Of D-Amino Acid Oxidase (DAAO) And NLRP3 Inflammasome, In Healthy Subjects: A Double-Blind, Placebo-Controlled, Randomized, Single Dose and Multiple Dose Phase I Study
Objective: To evaluate the safety, tolerability, and pharmacokinetics (PK) profile of YA-101 in healthy volunteers with single dose and multiple dose Background: Multiple System Atrophy…Peripheral immune profile and neutrophil-to-lymphocyte ratio in Progressive Supranuclear Palsy
Objective: This study aimed to evaluate the peripheral immune profile in patients with Progressive Supranuclear Palsy (PSP) compared with patients with Parkinson’s disease (PD) and…Environmental risk factors and demographic of patients with Progressive Supranuclear Palsy from Argentina
Objective: To describe the environmental risk factors and family history in Argentinian patients with diagnosis of progressive supranuclear palsy (PSP). Background: Background: The current epidemiology…Rapid Cognitive Deterioration and Related Factors in Progressive Supranuclear Palsy: a One-Year Follow-up Study
Objective: Based on a relatively large cohort, we aimed to show the switch of cognitive status in patients with progressive supranuclear palsy (PSP) after one-year follow-up…Decoding non-IPD Parkinsonism – A Comparative Analysis of Atypical and Secondary Parkinsonism
Objective: Using precise diagnostic criteria, the single-center observational study aims to evaluate the clinical profiles of non-IPD parkinsonism, specifically identifying crucial clinical clues for discriminating…Frequency of Falls as a Presenti̇ng Symptom and Its Effect i̇n Prognosi̇s i̇n Progressi̇ve Supranuclear Palsy
Objective: We aimed to evaluate frequency of falls as a presenting symptom and its effect on prognosis in PSP patients. Background: Progressive supranuclear palsy is…
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