Absence of identifiable neuropathological correlates of cognitive impairment in multiple system atrophy
Objective: To analyze neuropathological correlates of cognitive impairment in multiple system atrophy (MSA) and characterize the affected cognitive domains. Background: Current MSA census criteria delineate…Metabolic Patterns in Multiple System Atrophy: Brain Network Insights from Spatial ICA of FDG-PET
Objective: This study employs spatial independent component analysis (ICA) on 18F-fluorodeoxyglucose (FDG)-PET imaging to decompose metabolic heterogeneity in Multiple system atrophy (MSA), identifying key brain…Utilizing the 15-item modification of the PSPRS rating scale (mPSPRS-15) as the primary endpoint for future clinical trials in progressive supranuclear palsy
Objective: To compare the properties of PSPRS-28, mPSPRS-15, and the rPSPRS-10 and assess their utility as a primary endpoint in PSP trials. Background: Progressive supranuclear…Normal Pressure Hydrocephalus in Vestibular Schwannoma Patients
Objective: The first objective is to evaluate the potential pathophysiological link between vestibular schwannoma (VS) and normal pressure hydrocephalus (NPH) by analyzing clinical features, imaging…Novel Multiple System Atrophy Subtypes Identified Using Unsupervised Machine Learning Algorithms
Objective: To identify a novel disease subtype of multiple system atrophy (MSA) by applying machine learning algorithms to a large cohort of autopsy-confirmed MSA. Background:…The Radiographic Overlap Between Normal Pressure Hydrocephalus (NPH) and Progressive Supranuclear Palsy (PSP): When Looks Can Be Deceiving
Objective: To demonstrate the overlap on radiographic metrics between NPH and PSP. Background: The neuroradiological hallmark of NPH is non-obstructive ventriculomegaly (Evans’ index (EI) >0.3).…Topographical heterogeneity of cholinergic system status in Multiple System Atrophy: A series report
Objective: To characterize individual-level topographical patterns of cholinergic upregulation and downregulation in Multiple System Atrophy (MSA) using a whole brain voxel-wise approach. Background: MSA is…Quantitative Regional Tau Pathology and Spatial Transcriptomics Identify Signatures of Phenotypic Diversity in Progressive Supranuclear Palsy.
Objective: To determine the pathological and molecular determinants of phenotypic diversity in PSP. Background: PSP exhibits broad variability in clinical phenotype and progression, however the…4R-TAU seed amplification assay discriminates tauopathies from non-tauopathies and CBD from PSP in post-mortem brain samples
Objective: To investigate whether 4R-TAU seed amplification assay discriminates tauopathies from non-tauopathies as well as CBD from PSP in post-mortem brain samples. Background: 4 repeat…Low Level of Serum Total Cholesterol Predicts Mortality in Early-stage Multiple System Atrophy: a Prospective-cohort Study
Objective: The study aims to clarify the association between baseline level of serum TC and survival of patients with early MSA. Background: Serum total cholesterol…
- « Previous Page
- 1
- …
- 28
- 29
- 30
- 31
- 32
- …
- 1734
- Next Page »