Blood derived α-synuclein seeding in the course of Parkinson’s Disease
Objective: To identify seeding capacities of soluble α-synuclein (α-syn) conformers derived from neuronal extracellular vesicles (NEs) from Parkinson´s disease (PD) patients with different disease durations…Clinical and genetic characteristics of a cohort of 20 patients with confirmed biallelic pathogenic SPG7 mutations from the North West of England
Objective: To identify the prevalence and phenotype of patients with biallelic pathogenic SPG7 mutations Background: Spastic Paraplegia Type 7 (SPG7) is an autosomal recessive disorder…Two Distinctive Anatomic Location in Brain Tumor Patients with Secondary Parkinsonism Manifestation: A Serial Case Report
Objective: We reported two interesting cases report of brain tumor patients with different anatomic location presenting secondary parkinsonism Background: Movement disorders caused by brain tumors are rare. The literature…Clinical Profile Of Drug-Induced Movement Disorders In Cipto Mangunkusumo Hospital, Indonesia
Objective: We aimed to portray the clinical spectrum of Drug-induced movement disorders (DIMDs) in Cipto Mangunkusumo Hospital, Jakarta, Indonesia Background: DIMDs remain a significant burden…Effectiveness of speech therapy in patients with Parkinson’s disease – a randomized controlled trial
Objective: We aimed to assess the effectiveness of speech therapy on improving quality of life and speech quality in patients with Parkinson’s disease. Background: Although…Specific ethnicity could have different risk factors for Parkinson’s disease: a descriptive study
Objective: The objective of this study was to determine if there were different risk and protective factors for Parkinson’s disease (PD) based on subethnicity in…Evaluating continuous monitoring in Parkinson’s disease through real-world, device-reported outcomes.
Objective: This work presents an analysis of real-world, device-reported outcomes from patients in Greece, following a 6-month, continuous telemonitoring paradigm for Parkinson's disease. Results show…Comparison of biospecimens for α-synuclein seed amplification assays in Parkinson’s disease: A Systematic Review and Network Meta-Analysis
Objective: We performed meta-analysis to determine the diagnostic and differential diagnostic value of α-syn SAAs for PD, and to investigate the optimal specimens. Background: Alpha-synuclein…The impact of wearing ‘OFF’ (WO) episodes on non-motor symptoms (NMS) burden and quality of life (QoL) in Parkinson’s disease (PD) patients
Objective: To estimate the frequency and severity of NMS and their impact on QoL among patients with moderate to advanced PD with WO episodes versus…Patients activation in people with Parkinson disease and its relation to personal factors
Objective: To identify individual factors associated with patient activation among people with Parkinson’s disease (PD). Background: The concept of patient activation captures subjective aspects of…
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