Mutational effects of LRRK2 I1371V in astrocytes derived from patient specific iPSCs
Objective: To identify the LRRK2 I1371V mutational effects on astroglial biology involving glutamate metabolism and glutathione machinery. Background: The underlying cause of most of the familial…HAB-C murine model present reactive adult neurogenesis and astrogliosis in adult brain
Objective: To analyze the adult neurogenic response to a neurodegenerative process due to H-ABC tubulinopathy. Background: H-ABC is a neurodegenerative disease caused by mutations in…Structural connectivity affecting freezing of gait after globus pallidus internus deep brain stimulation in Parkinson’s disease
Objective: We aim to investigate how structural connectivity of the brain affects gait freezing after globus pallidus internus (GPi) deep brain stimulation (DBS). Background: Freezing…Bilateral GPi DBS for the treatment of a general dystonia with EIF2AK2 mutant: Report of globus pallidus local field potentials and the therapeutic outcome
Objective: We reported a generalized dystonia patient with eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2) gene mutation who underwent bilateral Globus pallidus interna…Botulinum toxin injections are an effective treatment for patients with essential head tremor.
Objective: To assess the safety and efficacy of Botulinum toxin (Btx) injections in essential head tremor (HT) in a multicenter, randomized, double blind, parallel-group, placebo-controlled…Mitochondrial and autophagy alteration in a new fatty acid hydroxylase-associated neurodegeneration (FAHN) model
Objective: Establishing a FAHN Drosophila model to identify cellular disease mechanisms. Background: Fatty acid hydroxylase-associated neurodegeneration (FAHN) is an early-onset neurodegenerative disease that manifests brain…Machine learning-based classification of SCA1, SCA2, and Healthy controls using graph features
Objective: To differentiate genetic variants of spinocerebellar ataxia (SCA1 and SCA2) and healthy controls using machine learning on resting-state functional Magnetic Resonance Imaging graph features.…Importance of lifestyle advice for participants in studies of early Parkinson’s disease
Objective: Estimating the ethical acceptability of early Parkinson’s Disease (PD) research among healthy individuals participating in a PD screening study in terms of risk disclosure…CCL5 promotes Th17 migrating into SNpc by promoting Th17 proportion increase and LFA-1 expression
Objective: To explore the specific pathway by which CCL5 induces Th17 cells migrating into substantia nigra pars compacta (SNpc) to aggravate Parkinson's disease (PD). Background:…DUtch PARkinson Cohort (DUPARC): Contrast Sensitivity and Retinal Changes in Early Parkinson’s Disease Patients
Objective: To identify and characterize the correlation between static contrast sensitivity (SCS), dynamic contrast sensitivity (DCS), and thickness of the internal plexiform layer (IPL) in…
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