Juvenile parkinsonism masquerading as hereditary spastic paraplegia
Objective: To present a patient with juvenile parkinsonism initially presented with billateral foot dystonia and inreased deep tendon reflexes. Background: Patients with juvenile parkinsonism may…Gait Analysis and Outcome of CSF Drainage in Patients of Normal Pressure Hydrocephalus
Objective: NPH is a clinical entity causing impairment in gait, bladder and memory functions. Of these, gait dysfunction is the most prominent and disabling as…Topographical heterogeneity of cholinergic system status in Multiple System Atrophy: A series report
Objective: To characterize individual-level topographical patterns of cholinergic upregulation and downregulation in Multiple System Atrophy (MSA) using a whole brain voxel-wise approach. Background: MSA is…Concomitant Progressive Supranuclear Palsy and Amyotrophic Lateral Sclerosis Versus Motoneuron Phenotype of PSP in Ukrainian Patient
Objective: To provide a description of a rare case of mixed progressive supranuclear palsy (PSP) and amyotrophic lateral sclerosis (ALS) in Ukrainian patient. Background: The…Normal Pressure Hydrocephalus in Vestibular Schwannoma Patients
Objective: The first objective is to evaluate the potential pathophysiological link between vestibular schwannoma (VS) and normal pressure hydrocephalus (NPH) by analyzing clinical features, imaging…Impact of manganese exposure on neurobehavioral disorders in rats: Insights into oxidative stress pathways and Parkinsonian syndrome pathophysiology
Objective: This study investigates the correlation between oxidative stress in various neural structures induced by manganese (Mn) and the onset of anxious and depressive behaviours…Subacute Unmasking of AD-CBS Subtype
Objective: To describe a unique case of Alzheimer's Disease in which olanzapine use resulted in unmasking an underlying corticobasal syndrome Background: Corticobasal Syndrome is a…A Quantitative Systems Disease Model for Progressive Supranuclear Palsy.
Objective: Developing a computer model integrating the PSP pathology to support clinical trial for new disease-modifying therapies Background: Progressive Supranuclear Palsy is a fast progressing…POLG2 Variant Reclassification Reveals Diagnosis in Adult with MSA-C Phenotype
Objective: (1) To emphasize the critical role of genetic evaluation in adult-onset movement disorders (2) to demonstrate that POLG2-related disorders should be considered in the…The Radiographic Overlap Between Normal Pressure Hydrocephalus (NPH) and Progressive Supranuclear Palsy (PSP): When Looks Can Be Deceiving
Objective: To demonstrate the overlap on radiographic metrics between NPH and PSP. Background: The neuroradiological hallmark of NPH is non-obstructive ventriculomegaly (Evans’ index (EI) >0.3).…
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