Clinical Deficits, Quality of Life and Caregiver Burden across PSP Phenotypes
Objective: To assess clinical deficits, quality of life and caregiver burden across progressive supranuclear palsy (PSP) phenotypes considering also other variables such as age, sex…Spatial Metabolic Covariance Networks in PSP: Implications for Symptomatology and their Neural Basis
Objective: This study aimed to apply spatial ICA to 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) data from PSP patients and healthy controls (HCs) to identify…Peripheral unspecific inflammatory parameters – not always useful in differential diagnosis of parkinsonian syndromes.
Objective: To determine utility of systemic inflammation response index (SIRI) and systemic immune-inflammation index (SII) in differential diagnosis of Parkinson’s disease (PD), progressive supranuclear palsy-Richardson’s…Multiscale entropy: a New Oculomotor Measure of PSP.
Objective: The objective of this study was investigate whether multiscale entropy, a measure of complexity, when applied to the path of unconstrained eye movements could…Conjugal Parkinsonism
Objective: To report a case of multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) in a couple. Background: Conjugal parkinsonism denotes an entity where…Alpha-Synuclein Promotes the Expression and Release of Neurofilament Light Chain from Oligodendrocytes in Multiple System Atrophy
Objective: This study aims to determine the Neurofilament light chain (NfL) expression in oligodendrocytes, investigate whether excess α-synuclein (α-syn) impacts NfL expression, release, and functions…Clinical Features Suggestive of Alpha-Synucleinopathy in Progressive Supranuclear Palsy
Objective: To compare the presence of symptoms suggestive of synucleinopathy between PSP-parkinsonism (PSP-P), Parkinson's disease (PD) and PSP-Richardson syndrome (PSP-RS). Background: Clinical signs with high…ATH434 Slowed Disease Progression in a Phase 2 Study in Multiple System Atrophy
Objective: Evaluate the efficacy and safety of ATH434 treatment in individuals with MSA Background: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder without…The importance of vascular anomalies and endothelin-1 factor in the development of vascular parkinsonism
Objective: To study the relationship between vascular endothelium and vascular anomalies in the development of vascular parkinsonism. Background: Although vascular parkinsonism (VP) is relatively rare,…Design and Outcome Measures of BRAVE, a Phase 3 Study of Omaveloxolone in Pediatric Patients With Friedreich Ataxia
Objective: This phase 3 randomized controlled trial will assess the efficacy and safety of omaveloxolone in children aged 2 to <16 years. Background: Omaveloxolone is…
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