Impact of istradefylline on the adjustment of levodopa dose escalation in Parkinson’s disease: Results of the ISTRA ADJUST PD randomized, controlled study
Objective: To evaluate the effect of istradefylline (IST), an adenosine A2A receptor antagonist, on the adjustment of levodopa dose escalation in patients with Parkinson’s disease…Pallidal firing rate and alpha oscillations correlate with the severity of clinical symptoms in patients with dystonia
Objective: To examined how pallidal activity correlates with symptom severity across dystonic patients. Background: The internal segment of globus pallidus (GPi) is the most common…APOE effect on Progressive Supranuclear Palsy phenotypes
Objective: To assess the influence of the Apolipoprotein E (APOE) gene variants on Progressive supranuclear palsy (PSP) phenotypic expression. Background: PSP is a rare neurodegenerative…Internal globus pallidus deep brain stimulation in ACTB-related deafness-dystonia
Objective: To describe the response to deep brain stimulation (DBS) in a patient with ACTB-related deafness-dystonia syndrome with three years of follow-up and to review…Color vision deficits in Parkinson’s disease are linked to brain abnormalities in attentional, fronto-pariental and visual networks
Objective: To analyze the relationship between color vision deficits in Parkinson’s disease (PD) and the integrity of the visual system, cognition and other relevant networks…Differences in cognition and neuropsychiatric profiles between asymptomatic and symptomatic carriers of Huntington’s disease
Objective: To analyze cognitive and neuropsychiatric differences between asymptomatic and symptomatic carriers of Huntington's disease (HD) compared with healthy controls (HC) taking into account the…Genetic landscape of dystonia in Asian Indian patients
Objective: To identify potentially pathogenic genomic variations associated with dystonia phenotypes in Asian Indian patients with dystonia. Background: The Asian Indian population is underrepresented in…Comparison of Disease Progression in Patients with Brain-first versus Body-first Parkinson’s Disease
Objective: This study aimed to compare the clinical progression between brain-first and body-first PD groups using cardiac sympathetic denervation (CSD). Background: Brain-first and body-first Parkinson’s…Developing New Insights Into Clinical and Genetic Features of PD – The Global Parkinson’s Genetics Program (GP2) Clinical Cohorts Working Group
Objective: We aim to recruit Parkinson’s cohorts across the world for the Global Parkinson’s Genetics Program (GP2, http://gp2.org/), harmonize clinical data for joint analysis and…The relationship of non-motor symptoms in Parkinson’s disease
Objective: Evaluation of non-motor symptoms in patients with Parkinson's disease, evaluation of the relationship of autonomic and neuropsychiatric disorders. Background: This work included a comprehensive…
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