Oligodendrocyte-Specific α-Synuclein Pathology is Linked to Severe Motor Phenotype in a Novel Mouse Model of Multiple System Atrophy
Objective: We characterized the formation of α-synuclein pathology and development of motor phenotypes in a mouse model of multiple system atrophy overexpressing human SNCA in…Partial Duplication of NBEA in a Patient Presenting Chorea with Incomplete Penetrance
Objective: To report a novel genotype-phenotype correlation involving a partial duplication of the NBEA gene in a patient presenting with chorea. Background: NBEA has been identified as…Postural Sway Frequencies in Isolated REM Sleep Behavior Disorder Might Indicate Subtle Motor Impairments as Prodromal Marker of Parkinson’s Disease
Objective: In this preliminary study, we aimed to compare postural sway between individuals with early, untreated Parkinson’s disease (PD), individuals with isolated REM sleep behavior…Cognitive Trajectories After STN DBS in Parkinson’s Disease: 12-Month Outcomes
Objective: To determine whether early postoperative cognitive changes occur across distinct domains following STN-DBS Background: Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is…Stimulation-Level Sweet-Spot and Connectivity Analysis of Pallidal DBS in Huntington’s Disease
Objective: To assess clinical outcomes and identify stimulation and structural connectivity patterns associated with motor improvement in Huntington’s Disease (HD) patients undergoing DBS. Background: DBS…The Sweet Smell of ON: Phantosmia During Motor Fluctuations After Initiation of Foslevodopa/Foscarbidopa Infusion Therapy
Objective: To report a unique case of phantosmia/olfactory hallucinations (OfH) emerging as a non-motor fluctuation after initiation of foslevodopa/foscarbidopa (LDp/CDp) infusion at a lower levodopa…Association of the GCH1 p.Ser80Asn variant with Parkinson’s disease in East Asian populations
Objective: To investigate the clinical relevance and PD risk associated with the GCH1 p.Ser80Asn variant. Background: Heterozygous variants in GCH1 are the most frequent cause…Longitudinal gait changes after unilateral and bilateral MRgFUS thalamotomy in Essential Tremor
Objective: To evaluate changes in gait parameters Essential Tremor (ET) patients treated with unilateral or bilateral Magnetic Resonance-guided Focused Ultrasound (MRgFUS) thalamotomy, and to assess…Cerebellar cholinergic denervation relates to impaired gait and cerebellocortical resting-state functional connectivity in Parkinson disease
Objective: The purpose of this cross-sectional study was to investigate the cholinergic denervation of the cerebellum and its contribution to impaired gait and cerebellocortical resting-state…Impact of Symptom-Specific Odorants on the Diagnostic Accuracy of Brief Olfactory Tests in Parkinson’s Disease
Objective: To evaluate whether the addition of PD symptom-specific odorants improves diagnostic accuracy in distinguishing patients with PD from healthy controls. Background: Parkinson’s disease (PD)…
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