Convolutional neural network for discriminating between Multiple System Atrophy and Healthy Control, comparing MRI modalities and highlighting the disease signature
Objective: To develop a neural network architecture based on multimodal MRI brain imaging to discriminate between multiple system atrophy (MSA) and healthy controls (HC), and…Visual cortex involvement in the familial cortical myoclonic tremor with epilepsy type 1: a resting state-fMRI with regional homogeneity analysis
Objective: The purpose of current study was to investigate regional synchronization of the whole brain in patients with familial cortical myoclonic tremor with epilepsy (FCMTE)…The relationship between MIBG myocardial scintigraphy and clinical factors in multiple system atrophy
Objective: This study aimed to clarified the relationship between the degree of MIBG accumulation and clinical factors in patients with MSA. Background: 123I-MIBG myocardial scintigraphy considered to…4-Chlorokynurenine inhibits L-Dopa-induced dyskinesias in non-human parkinsonian primates
Objective: This study investigated the antidyskinetic activity of 4-chlorokynurenine (AV-101) in parkinsonian monkeys with L-Dopa-induced dyskinesias. Background: The common treatment for Parkinson’s disease (PD) is L-Dopa…Copper induced neurobehavioral features of Parkinson’s disease and oxidative stress and their abatement by Eugenol
Objective: The aim of this study was to evaluate impact of copper intoxication (10 mg/kg B.W) for 3 days on locomotor performance and oxidative status,…hUC-MSCs ameliorated CUMS-induced depression by modulating complement C3 signaling-mediated microglial polarization during astrocyte-microglia crosstalk
Objective: To demonstrate whether hUC-MSCs can benefit depressive-like behavior by altering C3/C3a-C3aR signaling to impact microglia polarization in the CUMS model. Background: Major depressive disorder (MDD) has been…Perillyl alcohol restores mitochondrial dysfunction and abridge NLRP3 inflammasomes activation in in-vitro and in-vivo model of Parkinson’s disease
Objective: Parkinson's disease (PD) affects around 2-3% population of age greater than 65 and is the second most common neurogenerative disorder. The molecular mechanism underpinning…Neuroprotective effects of allicin microemulsion against intrastriatal rotenone and manganese induced Parkinsonism in rats
Objective: Allicin is flavonoid that possess neuroprotective potential but main impediment is its low bioavailability which was improved with microemulsion. The present study was framed…Preclinical pharmacology and early clinical development of dopamine D1 positive allosteric modulators (D1PAMs) with therapeutic potential for neuropsychiatric disorders
Objective: The objective was to characterize novel dopamine D1PAMs pre-clinically in behavioral and neurochemical models and in phase 1 human studies in healthy volunteers and…Oral treatment of the SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS) with the neuro-inflammation inhibiting compound PRI-003
Objective: Demonstration of beneficial effects of neuro-inflammation inhibition for the treatment of amyotrophic lateral sclerosis (ALS). Background: Neuro-inflammation and immune-inflammatory processes are characteristics of the…
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