MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

MENU 
  • Home
  • Meetings Archive
    • 2024 International Congress
    • 2023 International Congress
    • 2022 International Congress
    • MDS Virtual Congress 2021
    • MDS Virtual Congress 2020
    • 2019 International Congress
    • 2018 International Congress
    • 2017 International Congress
    • 2016 International Congress
  • Keyword Index
  • Resources
  • Advanced Search

Study of striatal dopamine transporter function in Alzheimer’s disease with parkinsonism

T. Yamamoto, A. Miyake, K. Ikeda, T. Furuya, T. Mitsufuji, Y. Ito, T. Sasaki, K. Takahashi, N. Tamura, I. Matsunari, A. Nobuo (Iruma-gun, Japan)

Meeting: 2016 International Congress

Abstract Number: 1350

Keywords: Dopaminergic neurons, Single-photon emission computed tomography(SPECT)

Session Information

Date: Wednesday, June 22, 2016

Session Title: Cognitive disorders

Session Time: 12:00pm-1:30pm

Location: Exhibit Hall located in Hall B, Level 2

Objective: To clarify the pathological basis for Alzheimer’s disease (AD) with parkinsonism using striatal dopamine transporter (DAT) scan.

Background: Pathological basis for parkinsonism in AD is still unclear, although neuronal loss in substatia nigra has been reported in AD patients with parkinsonism.

Methods: We evaluated the function of presynaptic dopamine neuron by DAT scan in 3 cases of AD with parkinsonism.

Results: Case 1. A 73-year-old woman: Memory loss appeared 4 years before DAT scan. Only cognitive impairment was seen (revised Hasegawa dementia scale; HDS-R score was 20), when she visited our department the next year. Z score of the parahippocampal gyrus (PHG) by Voxel-Based Specific Regional Analysis System for AD (VSRAD) was 1.40. Parkinsonism, which was dominant in the left side, developed 3.5 year after the onset. DAT scan performed in the next year revealed a decreased uptake in the (predominant right) striatum. Cardiac MIBG scintigraphy was normal. REM sleep behavior disorder (RBD) and autonomic symptoms have not been seen. Case 2. A 78-year-old woman. Memory problem developed 4 years before DAT scan. The HDS-R score was 16 and the Z-score of PHG was 1.26 after two years later. She presented the right-side predominant parkinsonism 4 years later from the onset. There was no history of visual hallucinations and RBD. MIBG uptake was normal. Slightly reduced uptake was observed in the left striatum on the DAT scan. Case 3. An 86-year-old woman: She developed memory problem 7 years before DAT scan. The four years later after the onset, HDS-R score was 8 points and Z score of PHG was 3.59. Parkinsonism,which was predominant in the right side, as well as hallucinations and RBD appeared 7 years after the onset. Decreased striatum uptake was predominant in the right striatum on the DAT scan. MIBG uptake was reduced. In all patients, brain SPECT showed the reduced blood flow in the temporal lobe and the posterior cingulate gyrus.

Conclusions: Since the nerve cell loss of substantia nigra has been reported in AD patients with parkinsonism, the impairment of DAT function may be induced with the progress of AD pathology in case 1 and 2, and by concomitant Parkinson’s disease in case 3. We should consider that parkinsonism in AD patients is caused not only by the concomitant Parkinson’s disease, but also by the process of AD pathology itself.

To cite this abstract in AMA style:

T. Yamamoto, A. Miyake, K. Ikeda, T. Furuya, T. Mitsufuji, Y. Ito, T. Sasaki, K. Takahashi, N. Tamura, I. Matsunari, A. Nobuo. Study of striatal dopamine transporter function in Alzheimer’s disease with parkinsonism [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/study-of-striatal-dopamine-transporter-function-in-alzheimers-disease-with-parkinsonism/. Accessed May 19, 2025.
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2016 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/study-of-striatal-dopamine-transporter-function-in-alzheimers-disease-with-parkinsonism/

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • An Apparent Cluster of Parkinson's Disease (PD) in a Golf Community
  • Covid vaccine induced parkinsonism and cognitive dysfunction
  • What is the appropriate sleep position for Parkinson's disease patients with orthostatic hypotension in the morning?
  • The hardest symptoms that bother patients with Parkinson's disease
  • Life expectancy with and without Parkinson’s disease in the general population
  • What is the appropriate sleep position for Parkinson's disease patients with orthostatic hypotension in the morning?
  • Increased Risks of Botulinum Toxin Injection in Patients with Hypermobility Ehlers Danlos Syndrome: A Case Series
  • Insulin dependent diabetes and hand tremor
  • Improvement in hand tremor following carpal tunnel release surgery
  • Impact of expiratory muscle strength training (EMST) on phonatory performance in Parkinson's patients
  • Help & Support
  • About Us
  • Cookies & Privacy
  • Wiley Job Network
  • Terms & Conditions
  • Advertisers & Agents
Copyright © 2025 International Parkinson and Movement Disorder Society. All Rights Reserved.
Wiley