Objective: The aim of the study was to compare the effects of curcumin and naringenin on rotenone-induced motor deficits and related neurochemical changes.

Background: Experimental data supports the use of phytochemicals as a preventive treatment for various Parkinson’s disease (PD) symptoms. Polyphenolic compounds such as curcumin and naringenin demonstrates neuroprotective action in neurodegenerative diseases. However, comparative role of natural products on PD-related features still unknown.

Method: In order to induce PD-like symptoms in Albino-Wistar rats, rotenone (1.5 mg/kg/day) was subcutaneously injected for 8 days. After 8 days of rotenone administration, rats received supplements of curcumin (100 mg/kg/day, p.o.) and naringenin (50 mg/kg/day, p.o.) for two weeks. The pole test, open field test, beam walking test, and footprint test were used to measure motor activity. Additionally, neurochemical estimation was also performed.

Results: Results of current investigation showed that curcumin and naringenin are more efficient in reducing the symptoms like PD induced by rotenone in rats. Curcumin significantly (p<0.01) modulated the neurotransmitter levels such as dopamine (DA), 5-hydroxytryptamine (5-HT), acetylcholine (ACh) and hence significantly (p<0.01) improved the motor activity, in rotenone toxicity. On the other side, naringenin exhibited more significant (p<0.01) effect on behavioral deficits and improved the motor coordination.

Conclusion: In conclusion, the findings suggest that a combination of particularly naringenin and curcumin supplements in daily life would be more effective in preventing and delaying the prevalence of PD.

References: [1] Zbarsky V, Datla KP, Parkar S, Rai DK, Aruoma OI, Dexter DT (2005). Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetinin a 6-OHDA model of Parkinson’s disease. Free Radic Res 39: 1119-1125. [2] Madiha S, and Haider S (2019). Curcumin restores rotenone induced depressive-like symptoms in animal model of neurotoxicity: assessment by social interaction test and sucrose preference test. Metabolic brain disease 34(1): 297-308. [3] Rice-Evans C (2001). Flavonoids antioxidants. Curr Med Chem 8: 797-807.2)

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MDS Abstracts - https://www.mdsabstracts.org/abstract/the-comparison-of-curcumin-and-naringenin-effects-on-motor-function-in-rotenone-model-of-parkinsons-disease/