Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To evaluate the factors associated with weight changes in Parkinson’s disease (PD) patients after deep brain stimulation (DBS) surgery.
Background: DBS is a well-established therapy for PD patients who cannot tolerate or be optimally managed with medications. Among possible side effects of the therapy, weight change post-DBS surgery is a phenomenon that has gained particular attention in the field, however it has only been addressed by very few small studies. Target selection, lead location and possible stimulation of structures including hypothalamus and nucleus accumbens (NA) are thought to play a role, however, the underlying mechanism and brain network responsible for the weight changes is yet to be elucidated.
Methods: This is a large retrospective cohort study evaluating Parkinson’s disease (PD) patients who underwent DBS surgery. We followed weight at different time-points, from pre-op up to 3 years post-surgery. We collected demographic data, clinical motor scales, and DBS-specific data including contact stimulated, and calculated the total electrical energy delivered (TEED) with the stimulation parameters used for each patient. To determine the possibility of electrical field interference in the function of hypothalamus or NA, we determined, for each subject, the tridimensional coordinates in the Cartesian plane for the active contact used and calculated the distance between active contact and hypothalamus or NA, for correlations with weight changes in the subgroups (STN and GPi). We utilized repeated measures ANOVA to describe variations in the mean weight of different subgroups (STN and GPi) across different time-points (baseline, 6 months, and yearly weights). We also utilized multiple logistic linear regressions to assess the impact of independent variables in weight changes across different subgroups. We assumed a p=0.05 for statistical significance.
Results: We expect to have 200 patients enrolled and analyzed by April 2016, with results to be presented at the 2016 MDS meeting.
To cite this abstract in AMA style:B. Ahmed, L.B. Almeida, A. Bona, S. De Jesus, D. Martinez-Ramirez, M.S. Okun. Weight changes in PD patients post-DBS: A look at the factors involved [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/weight-changes-in-pd-patients-post-dbs-a-look-at-the-factors-involved/. Accessed December 1, 2023.
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MDS Abstracts - https://www.mdsabstracts.org/abstract/weight-changes-in-pd-patients-post-dbs-a-look-at-the-factors-involved/