Levodopa/carbidopa intestinal gel treatment in advanced Parkinson’s disease: A long-term observational study
Objective: To evaluate long-term efficacy, levodopa dose changes and complications in patients with advanced Parkinson's disease (PD) treated. Background: Administrated via percutaneous gastric gastrostomy to…Effect of patient characteristics on motor function in response to 35–50 mg of inhaled levodopa (CVT-301) in patients with Parkinson’s disease: Results from a phase 2b study
Objective: To examine whether the response to an inhaled levodopa formulation (CVT-301; at 35 and 50 mg per dose) is dependent on baseline patient characteristics.…Improved motor functioning of people with Parkinson’s disease following dance intervention
Objective: To investigate the effectiveness of dance as an additional treatment for people with Parkinson's disease (PD). Background: Common pharmacological treatments for PD lessen the…Objective measures of Parkinsonian motor symptoms using a continuously worn smartwatch
Objective: To determine whether smartwatch sensor data correlates with clinician-measured Parkinson's disease symptoms. Background: Data collected with smartwatches could be used for long-term, continuous assessment…Safety and tolerability of inhaled levodopa (CVT-301) administered to Parkinson’s disease patients with motor fluctuations
Objective: Two Phase 2 studies were conducted to evaluate the safety profile of inhaled CVT-301 administered to Parkinson's disease (PD) patients with motor fluctuations. Background:…Efficacy of 4845 botulinum toxin (BoNT) treatment cycles, and clinical strategies after a failed cycle
Objective: To explore 1) relationship between peak benefit and Duration of Adequate Response (DAR) after BoNT, 2) frequency & causes of secondary Treatment Failure (TF),…Copper chelation efficacy of alginate/chitosan based D-penicillamine nanoparticles in rat model of non-Wilsonian brain copper toxicosis
Objective: To evaluate the copper (Cu) chelation efficacy of orally administered D-penicillamine loaded nanoparticles to that of conventional D-penicillamine therapy for 90 days in Wistar…A double-blind randomized controlled trial of cognitive training for freezing of gait in Parkinson’s disease
Objective: To investigate the potential of cognitive training to improve symptoms of freezing of gait in Parkinson's disease. Background: Freezing of gait (FOG) is a…Lead angle matters: Side effects of deep brain stimulation improved with adjustment of lead angle
Objective: A variety of technical considerations influence the outcome of Deep Brain Stimulation (DBS). We highlight a case where revising the angle of approach significantly…Non-motor outcomes of subthalamic stimulation in Parkinson’s disease depend on the location of active contacts
Objective: To investigate the impact of active electrode contact location on non-motor outcomes in patients with Parkinson's disease (PD) and subthalamic nucleus (STN) deep brain…
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