Frequency of GBA1 and LRRK2 G2019S mutations, and body mass index in Ashkenazi Jews
Objective: To evaluate the frequency and characteristics of parkinsonism and Parkinson's disease (PD) attributable to LRRK2 G2019S and Glucocerebrosidase1 (GBA1) mutations in Ashkenazi Jewish (AJ)…Risk of movement disorders with antipsychotic drugs in patients with schizophrenia or depressive disorders
Objective: To compare the risk of movement disorders with antipsychotic drugs (APDs) in patients suffering from Schizophrenia or Depressive Disorders. Background: APDs are well-known causes…Magnetic resonance characteristic of Parkinson’s disease based on the presence of cognitive impairment
Objective: To study the performance of MRI in patients with Parkinson's disease, depending on the stage of the disease. Background: Steadily progressive chronic neurodegenerative disease…Auditory function and speech discrimination abilities are impaired in progressive supranuclear palsy
Objective: To find out hearing ability and speech discrimination of progressive supranuclear palsy (PSP) patients, we performed audiological evaluation by means of Pure Tone (PTA)…Loss of FBXO7 (PARK15) leads to disturbances in proteasomal function and models parkinsonism-like and pyramidal symptoms in mice
Objective: To model Parkinsonian-pyramidal syndrome (PARK15) in mice and investigate the impact of loss of F-box only protein 7 (FBXO7) in neurons on proteasomal activity.…Initial clinical description of progressive supranuclear palsy in the Luxembourg Parkinson’s study
Objective: To characterize the clinical features and prevalence of patients with progressive supranuclear palsy (PSP) in the recently implemented longitudinal Parkinson's cohort (HELP-PD). Background: PSP…Comparative analysis of freezing of gait in distinct parkinsonism types by diffusion tensor imagining and cognitive profiles
Objective: To demonstrate possible disturbances in pedinculopontine nucleus (PPN) and its connections in freezing of gait (FOG) by DTI in conjunction with the cognitive profile.…Sleep deprivation (SD) amongst carers of patients with Parkinson’s disease (PD)
Objective: To identify nocturnal symptoms in patients which lead to sleep deprivation in carers of PD patients. Background: SD affects the health status of the…Hypothalamic alpha-synuclein pathology and its relation to non-motor symptoms and disease progression in Parkinson’s disease
Objective: To assess alpha-synuclein pathology and tyrosine hydroxylase (TH) immunoreactivity as a dopaminergic marker in three hypothalamic nuclei with potential clinical implications (paraventricular, supraoptic and…Chronic levodopa treatment accelerates the disorders of circadian rhythm in 6-OHDA induced Parkinson’s disease model
Objective: We aimed to study the effect of levodopa on circadian rhythms in 6-OHDA lesioned rats, and to clarify whether the disturbance of the circadian…
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