Cholinergic basal forebrain atrophy and cognitive decline in advanced Parkinson’s disease
Objective: To examine the relationship between cognitive decline and atrophy across cholinergic basal forebrain (BF) subregions in advanced Parkinson’s disease (PD). Background: Recent studies show…The relationship between REM sleep behavior disorder and cognitive impairment in drug-naïve Parkinson’s disease
Objective: We aim to compare the cognitive performances of drug-naïve PD patients who had RBD (PD-RBD) to PD patients without RBD (PD-NRBD) and healthy controls.…Associations between subjective and objective cognitive decline in Parkinson’s disease
Objective: To evaluate associations between objective and subjective cognitive function over time in Parkinson’s disease (PD) using data from a clinical trial that enrolled patients…Anticholinergic Use in Parkinson’s Disease: Practice Patterns in Patients with Cognitive Impairment
Objective: To explore utilization of anticholinergic medications using the Parkinson Foundation Quality Improvement Initiative (PF-QII) registry. Background: Recent publications have highlighted the association between anticholinergic…Cerebral microvascular injury provoked by alpha-synuclein preformed fibrils exacerbates cognitive dysfunction in Parkinson’s disease
Objective: The aim of this study was to investigate the role of microvascular pathology between abnormal αSyn aggregation and PD cognitive dysfunction. Background: Higher plasma…Northwestern University Feinberg School of Medicine Parkinson’s disease and Movement Disorders Center Biorepository: bringing the clinic and lab together
Objective: To establish a biobank of DNA and tissue samples from a population of movement disorder patients, their family members and healthy controls recruited from…Association between SNCA and clinical phenotypes of Parkinson’s disease in southern Chinese
Objective: The aim was to investigate the association between SNCA and clinical phenotypes of Parkinson’s disease (PD) in southern Chinese. Background: SNCA gene plays an…Sensitive biomarker of Parkinson’s disease linked to mutations in the glucocerebrosidase gene
Objective: To find a biomarker for development of Parkinson’s disease (PD) in carriers of mutations in the glucocerebrosidase gene (GBA). Background: Mutations in the GBA…Utility of multigene panel testing for diagnosing parkinsonism and dystonia in a large cohort of >500 patients
Objective: Evaluate the utility of multigene Next-Generation Sequencing (NGS) for molecular diagnosis of parkinsonism and dystonia. Background: Parkinson's disease (PD) and dystonia are common neurodegenerative…Screening of mutations in PARK2 gene and Dopamine levels in Parkinson’s disease (PD) patients in Coimbatore population, India
Objective: The aim of the present study was to perform the mutational screening of PARK2 gene and dopamine level in PD patients of Coimbatore population,…
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