Predicting the influence of deep brain stimulation on Parkinson’s disease gait freezing
Objective: Before the deep brain stimulation of the subthalamic nucleus (STN-DBS) an individual patient clinical predictor would be useful to inform the patient about freezing…Blood hexokinase reduction in de novo Parkinson’s disease and remodeling of glycolytic energy homeostasis with L-DOPA/Istradefylline combination therapy
Objective: To evaluate the glycolytic energy homeostasis in Parkinson’s disease (PD), and to define the effects of PD pharmacotherapies on glycolytic dynamics Background: Neuronal energy…Gut Microbiote Distinctive Features and Microbiota-Metabolome Profile in Parkinson’s Disease: Focus on Levodopa and LCIG
Objective: The aim of this work was to study the microbiome of PD patients, studying the effect of dopaminergic drugs mainly focusing on the effect…Effectiveness of dopaminergic drugs on motor symptoms in Parkinson’s disease patients with deep brain stimulation of subthalamic nucleus
Objective: To compare the effectiveness of dopaminergic drugs on motor symptoms assessed by UPDRS- III in Parkinson’s disease patients pre and post deep brain stimulation…Effect of opicapone and entacapone on early morning-OFF pattern in Parkinson’s disease patients with motor fluctuations
Objective: To evaluate the effect of opicapone (OPC) 50 mg versus entacapone (ENT) on early morning-OFF (EMO) pattern. Background: OPC, a once-daily catechol-O-methyltransferase inhibitor, was…CHCHD2 mRNA levels in erythrocyte are reduced in patients with multiple system atrophy
Objective: To investigate CHCHD2 mRNA expression of erythrocyte in patients with multiple system atrophy (MSA). Background: Coiled-coil-helix-coiledcoil-helix domain containing 2 (CHCHD2) are reported to be associate with…Clinical features and natural course of corticobasal degeneration and progressive supranuclear palsy presenting as corticobasal syndrome
Objective: To compare clinical features and natural course of corticobasal degeneration (CBD) presenting as corticobasal syndrome (CBD-CBS) and progressive supranuclear palsy presenting as corticobasal syndrome…The Progressive Supranuclear Palsy Clinical Deficits Scale
Objective: To develop a scale to monitor clinical deficits in patients with Progressive Supranuclear Palsy across its broad phenotypes. Background: There is currently no undisputed,…Atypical parkinsonism due to a mutation in the SLC9A6 gene
Objective: Expanding phenotypic spectrum in christianson syndrome (CS). Background: CS is an X-linked neurodevelopmental disorder characterized by intellectual disability combined with microcephaly, cognitive impairment, ataxia,…Multi-level and multi-pattern lower- and upper-limb spasticity treatment with incobotulinumtoxinA in children and adolescents with cerebral palsy
Objective: Assess efficacy and safety of incobotulinumtoxinA in lower-limb (LL) or combined LL/upper-limb (LL/UL) spasticity in children and adolescents with cerebral palsy (CP). Background: Ambulant…
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