Parkinson’s Disease, Cognition, Positive Symptoms and Medication Management
Objective: Explore the relationship between multi-domain cognitive testing and patient-reported psychiatric symptoms in PwPD to self-medication management capabilities. Background: Parkinson’s disease (PD) is a complex…Cerebro-cerebellar motor networks in clinical subtypes of Parkinson’s disease
Objective: This study investigated functional alterations within the cerebro-cerebellar system in tremor-dominant (TD) and postural-instability-and-gait-disorder (PIGD) subtypes of Parkinson’s disease (PD) using stepwise functional connectivity…Reduced Risk of Mortality and Antipsychotics in Parkinson’s Disease-Related Psychosis: Pimavanserin vs Off-Label Antipsychotics
Objective: Summarize the available data for the mortality risk associated with Parkinson’s disease (PD) psychosis (PDP) and pimavanserin. Background: PDP is associated with increased mortality…Developmental Validity of the revised improved version of the Fragile X-associated Tremor Ataxia Syndrome Rating Scale (FXTAS-RS)
Objective: To qualitatively validate the revised improved version of the Fragile X-associated Tremor Ataxia Syndrome Rating Scale (FXTAS-RS) for motor signs assessment. Background: Clinimetric analyses…Amelioration of Levodopa-induced Dyskinesias using Genetic Silencing of Striatal CaV1.3 in Parkinsonian Rats: Impact of Sex and Advancing Age
Objective: To advance understanding of striatal CaV1.3 (cacna1d) channel silencing as a therapeutic approach to reduce levodopa-induced dyskinesias (LID), a side effect of long-term escalating…Symptomatic brain calcifications in two patients with JAM2 monoallelic variants.
Objective: To describe two subjects carrying monoallelic JAM2 genetic variant associated with brain calcification. Background: Primary Familial Brain Calcification (PFBC) is a rare neurodegenerative disorder…ASYMMETRIC EARLY-ONSET PARKINSONISM DUE TO PSEN1 MUTATION
Objective: To report a novel case of early-onset parkinsonism due to a presenilin 1 gene (PSEN1) mutation. Background: Mutations in PSEN1 gene are the most…“Happy fix” transiently improves cervical dystonia
Objective: To describe an emotional trick that has not been described in patient with cervical dystonia. Background: Geste antagoniste is a sensory trick that can…A randomized, sham-controlled, crossover trial on Transcranial pulsed current stimulation (tPCS) in Huntington disease
Objective: 1. To assess brain network level dysfunction of Huntington disease (HD). 2. To evaluate the effectiveness of 2-week home-based chronic non-invasive transcranial brain stimulation (NIBS) in…Has the COVID-19 pandemic had an impact on Functional Movement Disorders phenotype?: experience from a specialized Unit in Spain.
Objective: To assess the prevalence of paroxysmal functional movement disorders (PFMD) seen in a specialized Unit before and after the COVID-19 pandemic. Background: COVID-19 pandemic…
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