A mouse model to test the cortical pathogenic theory of Parkinson’s disease
Objective: To develop a mouse model of chronic corticostriatal overactivity and increase expression of corticostriatal alpha-synuclein. Background: Parkinson’s disease typically has a focal motor onset1,…Neurodegeneration and neuroinflammation for biomarker development in MSA
Objective: To investigate the diagnostic and prognostic value of fluid-based and PET imaging biomarkers related to neurodegeneration and neuroinflammation in Multiple System Atrophy (MSA). Background:…Excessive tearing; a paradoxical ocular manifestation of Parkinson’s disease
Objective: To demonstrate a case report of excessive tearing in Parkinson’s disease patient Background: Dry eye is the common ocular manifestations in PD patients. The…Alteration of peripheral blood cell profiles in Parkinson’s disease: a retrospective case-control study
Objective: The aim of this study is to investigate the relationship between peripheral blood cell profiles and Parkinson's disease (PD). Background: Abnormal immune response and systemic inflammation have…Characterization of essential tremor patients in a central hospital-based sample.
Objective: Determine characteristics of essential tremor (ET) patients in a hospital-based sample. Background: Essential tremor is the most frequent movement disorders, with an estimated prevalence…Characteristics of Fatigue and Correlation with the Symptoms of Parkinson’s Disease
Objective: We aims to assess the frequency and severity of fatigue, to explore the clinical features and associated factors of fatigue, as well as to…in vivo and autopsy validation of alpha-synuclein seeding activity using RT-QuIC assay in the gastrointestinal tract of patients with Parkinson’s disease
Objective: To evaluate pathologic alpha-synuclein (AS) seeding activity with Real-time quaking-induced conversion (RT-QuIC) assay using formalin fixed paraffine-embedded (FFPE) tissue of GI tract in Parkinson's disease (PD)…Dyskinesia profiles after dose challenges with L-dopa vs L-dopa plus ropinirole: a pilot study
Objective: To investigate possible differences in the profiles of abnormal involuntary movements (AIMs) in patients with Parkinson’s disease (PD) after dose challenge with L-dopa alone…Therapy resistant tremor in Parkinson’s disease. Satisfying an unmet need.
Objective: Investigation on Parkinson's patients with therapy-resistant tremor usingapomorphine-pen injection for alleviation of resting tremor. Background: In Parkinson’s disease one of the major disturbing symptoms…Case Report: Deep Brain Stimulation as a Potential Treatment for Stiff-Person Syndrome
Objective: To our knowledge, there have not been any reports of deep brain stimulation (DBS) used in the treatment of stiff-person syndrome (SPS) in the…
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