Pupil response is impaired in clinically isolated REM Sleep Behavior Disorder and Parkinsons’ Disease
Objective: Since easily accessible (bio-) markers are needed to predict progression and outcome in prodromal stages of neurodegenerative diseases this study was designed to evaluate…Modifying clinical and electrophysiological parameters through Transcranial pulsed current stimulation (tPCS) in Huntington disease
Objective: 1. To assess brain network dysfunction of Huntington disease (HD). 2. To evaluate the effectiveness of 2-week home-based chronic non-invasive transcranial brain stimulation to…Alterations of the Right Olfactory Orbitofrontal Cortex and olfactory impairment in Parkinson’s Disease
Objective: To explore the potential role of the right olfactory orbitofrontal cortex in olfactory dysfunction (OD) in Parkinson’s Disease (PD). Background: The orbitofrontal cortex (OFC)…Clinical toolkits to improve conversations about Parkinson’s dementia
Objective: To co-produce, with people living with Parkinson’s and professionals, a pair of toolkits to improve conversations about Parkinson’s dementia in the clinic: one for…Thymoquinone and Edible Bird Nest: The Secret Ingredients to Protect Against MPTP-induced zebrafish Parkinson’s disease
Objective: Objectives: to create and validate an MPTP neurotoxin-based zebrafish model of Parkinson's disease and explore the therapeutic potential and neuroprotective effects of thymoquinone and…Prevalence of cardiovascular drugs and oral anticoagulants use among persons with and without Parkinson’s disease
Objective: We investigated prevalence of Cardiovascular drugs and Oral anticoagulants (OAC) use among community-dwelling persons with and without Parkinson's disease (PD) in relation to PD…Glycated alpha-synuclein and it emerging role in early onset of Parkinson’s disease
Objective: To elucidate, the molecular mechanism underlying glycated α-Syn mediated dopaminergic (DAergic) neurodegeneration in the substantia nigra (SN) via the AGE/RAGE signaling pathway. Background: Intracytoplasmic…Parkinson’s disease (PD) progression is associated with past exposure to organic contaminants in water at Marine Corps Base Camp Lejeune
Objective: To test whether PD progression is more rapid in individuals who were exposed to volatile organic compounds in the water supply at Camp Lejeune…Age-associated changes in the striatal proteins in aging Asian-Indians
Objective: To examine the age-related changes in tyrosine hydroxylase (TH), vesicular monoamine transporter2 (VMAT2), post-synaptic density protein-95 (PSD-95) and dopamine receptors (D1R, D2R) expression in the…An evaluation of NBI-827104 for essential tremor: results from a randomized, double-blind, placebo-controlled, dose-escalation, crossover study
Objective: To evaluate the efficacy of NBI-827104 in patients with essential tremor (ET). Background: NBI-827104 is a T-type calcium channel blocker that demonstrated tremorolytic activity…
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