Apomorphine effects on Parkinson’s disease fluctuation related pain: a pilot study
Objective: To evaluate the effect and safety of subcutaneous apomorphine as a treatment for fluctuation-related pain in Parkinson's disease (PD). Background: Pain is one of…The Blood-Brain Barrier Integrity and Prevalence of Intrathecal T Helper 17.1 Cells in Huntington´s Disease
Objective: The aim of the study was to investigate the potential role of cerebrospinal fluid (CSF)/plasma albumin quotient (Q-Alb) as a biomarker for blood-brain barrier…Levodopa-entacapone-carbidopa intestinal gel infusion for Parkinson’s disease: An analysis of data collected from the Swedish national register of Parkinson’s disease.
Objective: To investigate efficacy, tolerability, and safety of levodopa-entacapone-carbidopa intestinal gel (LECIG) in Parkinson’s disease. Background: LECIG was introduced in 2019. The approval was based…Efficacy of subthalamic nucleus deep brain stimulation in Parkinson’s disease: A preliminary Thailand experience
Objective: To evaluate the efficacy and adverse events of subthalamic nucleus deep brain stimulation (STN-DBS) in Thai patients with Parkinson’s disease (PD). Background: Bilateral STN-DBS…The role of depression in the development of Impulse Control Disorders in Parkinson´s Disease.
Objective: We aimed to investigate whether depression is associated with a higher risk of developing impulse control disorders (ICD) in Parkinson´s disease (PD) patients and…New DBS targets for dystonia in thalamus and brainstem
Objective: Our objective is to describe experience with new targets for deep brain stimulation in children with genetic or acquired dystonias. Background: Although DBS has…A Systematic Review of the Type, Timing, Frequency and Durability of Effect in Parkinson’s Disease Physical Therapy
Objective: To evaluate all current evidence on the types, timing, frequency, duration, and outcomes of physical therapy (PT) regimens applied in Parkinson’s disease (PD). Background:…Prevalence of cogwheel phenomenon in Parkinson disease
Objective: To examine the prevalence of cogwheel rigidity (CWR) in a cohort of Parkinson disease (PD) patients Background: First noted in a 1901 publication, CWR…Glucocerebrosidase (GCase) activator, Ambroxol, reduces alpha-synuclein serine-129 phosphorylation and oligomers in mutant LRRK2 R1441G mouse brains
Objective: To explore whether inducing brain GCase activity by Ambroxol™ (ABX; a brain-penetrant GCase activator) can reduce a-synuclein (αSyn) serine-129 phosphorylation and oligomer accumulation in…Functional circuit abnormalities in Levodopa-induced dyskinesia in Parkinson’s disease: A systematic review
Objective: Levodopa-induced dyskinesia (LID) in Parkinson’s disease (PD) are involuntary movements caused by long-term treatment with dopaminergic replacement therapy (levodopa). During the cause of PD,…
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