Combination of clinical and gait measures to classify fallers and non-fallers in Parkinson’s disease
Objective: To identify clinical and objective gait measures that best discriminate fallers from non-fallers in Parkinson’s disease (PD), with suggestions of optimal cutoff scores Background:…Does baseline expectation of benefit predict outcome in SURE-PD3, a Randomized, Double-Blind, Placebo-Controlled, Phase III trial of Inosine in Parkinson’s disease?
Objective: To evaluate the association of patient-reported baseline expectation with efficacy outcomes in a randomized placebo-controlled trial (RCT) in PD. Background: Expectation of benefit can…Olfactory neurons’ Substance P is highly expressed in Parkinson’s disease reflecting gastrointestinal dysfunction
Objective: To elucidate the role of Substance P in PD through molecular characterization of patients’ olfactory neurons. Background: Substance P is a neuropeptide largely expressed…Parkinson’s disease-associated psychosis in a Brazilian sample: worse cognitive outcomes, higher LEDD and longer disease duration.
Objective: To describe the prevalence of Parkinson's Disease (PD) associated psychosis (PDAP) at a Brazilian movement disorders outpatient and to evaluate its associated factors. Background:…Huntington’s disease-like 2 phenotypes: a case series from a Brazilian referral center
Objective: To describe the clinical phenotypes of Huntington’s disease-like 2 patients in a referral movement disorders (MD) center in Brazil. Background: Huntington's disease-like 2 (HDL2)…Case of neuroferritinopathy with isolated dystonic leg cramps and normal neuroimaging
Objective: To describe a case of genetically proven neuroferritinopathy with isolated dystonic leg cramps and normal neuro-imaging. Background: Neuroferritinopathy(NF) is an autosomal dominant condition characterized…Subanesthetic infusion of ketamine produces long-term reduction in levodopa-induced dyskinesia and depression in individuals with Parkinson’s Disease
Objective: An open-label, dose-finding Phase I/II clinical trial was conducted to test safety and tolerability of low-dose ketamine infusion to treat levodopa-induced dyskinesia (LID), and…Computerized assessment of Handwriting in Parkinson’s Disease Before and After Dopaminergic Medication
Objective: Computerized assessment of dysgraphia to evaluate dopaminergic medication effects on the handwriting of newly diagnosed PD patients. Background: Dysgraphia is a common motor symptom…Gender-specific differences of gait in parkinsonian syndromes
Objective: The aim of this study was to further assess gender-specific gait and balance differences related to fall frequency in APD and IPD patients. Background:…Associations of IL-1β and IL-6 gene polymorphisms with Parkinson’s disease(PD)
Objective: We aim to explore the associations of IL-1β and IL-6 gene polymorphisms with the pathogenesis of PD and with clinical features of motor and…
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