Decrease in Walking Ability with Increased Functional Connectivity between Multiple Brain Areas in Parkinson’s Disease
Objective: To compare the functional connectivity of PFC, PMC, and PSC regions during walking between individuals with Parkinson's disease and healthy controls. Background: Gait disturbances…Automated Imaging Differentiation of Parkinsonism (AIDP): A Prospective 21-site Trial within the Parkinson’s Study Group
Objective: To prospectively test the performance of Automated Imaging Differentiation of Parkinsonism (AIDP), a machine learning based diagnostic biomarker software for Parkinson’s disease (PD), multiple system atrophy Parkinsonian…Inflammation Biomarkers and Free Water Fraction in the Cholinergic Forebrain System in Idiopathic Parkinson’s Disease
Objective: Investigate if inflammatory biomarkers moderate the association between, cholinergic basal forebrain free water fraction and cholinergic innervation in idiopathic Parkinson’s disease. Background: The cholinergic…Naturalistic walking in Parkinson’s disease: Prefrontal cortex activity measured with functional near-infrared spectroscopy (fNIRS)
Objective: In persons with Parkinson’s disease (PwPD), to observe brain activity in prefrontal cortex (PFC) using fNIRS during naturalistic walking that mimics everyday scenarios1, with…Cognitive Outcome in Pantothenate Kinase-Associated Neurodegeneration (PKAN) Treated with Deep Brain Stimulation (DBS):Case Report
Objective: To assess cognitive outcome in PKAN treated with DBS Background: PKAN is a rare neurodegenerative disorder with pediatric onset & dystonic features. Motor symptoms…Treatment of Severe Tardive Syndrome with Pallidotomy: A Case Report
Objective: To present a case of severe tardive syndrome (TS) successfully treated with MRI-guided laser interstitial thermal therapy (LITT) unilateral pallidotomy and discuss its implications.…Prolonged Positive Response: Subthalamic Nucleus as a Deep Brain Stimulation Target in X-linked Dystonia-Parkinsonism
Objective: To demonstrate long-term improvement of parkinsonism and dystonia in patients with X-linked dystonia-parkinsonism (XDP) following deep brain stimulation (DBS) in the subthalamic nucleus (STN).…Is GPI DBS as effective to STN DBS for tremor control in Parkinson’s disease?
Objective: To compare the benefits of GPI and STN DBS on tremor in Parkinson’s disease (PD). Background: DBS is a highly effective surgical therapy for…Unilateral MRgFUS subthalamotomy in Parkinson’s disease: A prospective clinical study
Objective: To study the efficacy and safety of this treatment in a similar cohort of patients and to characterize the lesions. Background: Unilateral subthalamic nucleus…Focused Ultrasound Thalamotomy for Tremor-Dominant Parkinson Disease – Ablation Volume and Dentatorubrothalamic Tract Overlap Does Not Predict Outcome
Objective: To report the long-term outcomes in Tremor-Dominant Parkinson Disease (TDPD) after a unilateral Focused Ultrasound (uni-FUS) thalamotomy and explore factors that may predict the…
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