Melatonin Modulates NLRP3 Inflammasome Activation through TLR2 to Protect Against Parkinson’s Disease
Objective: This study aims to investigate the impact of MLT on inflammation signaling pathway mediated by TLR2 in α-synuclein (α-syn) overexpressed BV2 cells and PD…Genetic signatures stratify PwP into three subgroups with differing responses in two disease-modifying Phase 3 trials and indicate multiple disease biology pathways to Parkinson’s Disease
Objective: To evaluate if 3 newfound genetic subgroups represent differing aspects of disease biology in PD by determining if subgroup participants have differing responses to…Age and Parkinson’s disease: clinical and biomarkers profiling of younger and older patients
Objective: Given the well-known clinical differences and natural history of Parkinson's disease (PD) according ot patients age, wthis study aims at exploring the different pathophysiological…Cortical and Subcortical Brain Volume Changes in Idiopathic REM Sleep Disorder Subjects at Risk for Parkinson’s Disease
Objective: To quantify cortical and subcortical brain volumes using structural MRI analysis in idiopathic REM sleep behavior disorder (iRBD) subjects at risk for Parkinson`s disease…Frontal atrophy in progressive supranuclear palsy[PSP] -an universal feature along with midbrain atrophy?
Objective: To see if frontal atrophy is a frequent radiologic feature of PSP on MRI imaging . Background: Progressive supranuclear palsy[PSP] is a taupathy that…Identification of Brain Atrophy Subtypes in Prodromal and Overt Synucleinopathies: A Multicenter Study
Objective: To identify unique subtypes of synucleinopathy with distinct spatiotemporal patterns and trajectories of brain atrophy and disease burden. Background: The synucleinopathies manifest as a…Clinical and Brain Morphological Characteristics of Early LRRK2-associated Parkinson Disease
Objective: To investigate the impact of LRRK2 mutation in Parkinson disease (PD) and to explore the preclinical markers of LRRK2 mutation carriers who will develop…Associations between Choroid Plexus and tau in Parkinson’s Disease
Objective: To investigate the associations between the choroid plexus (ChP) and protein indicators of Parkinson’s Disease (PD). Background: The ChP is the primary organ that…Data-driven image-based subtyping and staging of neurodegeneration in Parkinson’s disease
Objective: We aimed to conduct image-based, data-driven classification of Parkinson’s disease (PD) progression using event-based modeling (EBM) and derive neuropathological insights from the results. Background:…Regional Brain Volume Differences Across PD Clinical Subtypes
Objective: To investigate brain morphometric differences across Parkinson disease (PD) clinical subtypes. Background: We developed a PD subtype classification with three subtypes that includes motor…
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