Pregnancy in Parkinson’s disease: Five cases
Objective: To report additional cases to the literature of Parkinson’s disease (PD) and pregnant. Background: Pregnancy in PD is a relatively rare occurrence as PD…Levodopa-Entacapone-Carbidopa Intestinal Gel in the treatment of advanced Parkinson’s disease: a two-year experience
Objective: To evaluate the efficacy of Levodopa-Entacapone-Carbidopa Intestinal Gel (LECIG) in the treatment of patients with advanced Parkinson’s Disease (APD). Background: The continuous enteral infusion…Rora deficiency aggravates dopamine neurons loss via reducing NAD+ level in Parkinson’s disease
Objective: To investigate the mechanism by which retinoic acid-related orphan receptor alpha(RORα) regulates NAD+ levels to dopamine neuronal degeneration in Parkinson’s Disease (PD). Background: PD is an age-related degenerative…Exploring the Therapeutic Target for Lewy Body Disease using gba1 Knock-out Medaka
Objective: This study was performed to explore the therapeutic target for Lewy body disease. Background: Lewy body disease (LBD), including Parkinson's disease and diffuse Lewy…Rationale for LRRK2 inhibition in sporadic Parkinson’s disease and the LUMA trial
Objective: To summarize the rationale for LRRK2 inhibition in sporadic PD patients without LRRK2 mutations, and to describe the current design of the LUMA study,…Declining Lymphocyte Count and Lymphocyte-to-Neutrophil Ratio Following Parkinson’s Disease Diagnosis.
Objective: To replicate previous findings in a diverse East London population, further characterising changes in FBC constituents and evaluating their temporal association with PD diagnosis.…Reaching Kinematics in Movement Disorder Patients Using an Open-Source Computer Vision Technology
Objective: In this study, we compared kinematic parameters of reaching task between SCA12 and healthy control participants using a novel tracking device. Background: Reaching for…Alterations of NAD metabolism in symptomatic and asymptomatic carriers of pathogenic GCH1 variant
Objective: To investigate whether carriers of pathogenic GCH1 variant reveal lower NAD levels in the basal ganglia or the cerebellum compared to variant-free controls. Background:…White matter abnormalities in motor subtypes of Parkinson’s disease
Objective: To evaluate white matter microstructural integrity in Tremor dominant Parkinson’s disease (TDPD) and postural instability and gait disturbance (PIGD) subtypes of PD to ascertain…Longitudinal change in brain function and structure related to plasma neurofilament light protein in early-stage Parkinson’s disease
Objective: We aimed to explore the relationship between the pNfL and change in the brain in early-stage PD using a longitudinal brain imaging cohort. Background:…
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