Effects of Deep Brain Stimulation on Sleep Disturbances in Parkinson’s Disease: a 4-Year Follow-Up Study
Objective: The aim of this study was to examine the effects of bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) on sleep disturbances (SD) in…Non-Motor Symptom Comparisons by Race/Ethnicity in Thousands with PD Diagnosis
Objective: To compare the incidence of non-motor symptoms (NMS) across racial and ethnic groups among individuals diagnosed with PD using the TriNetX platform, a global…Determining the Influence of Cardiovascular Interventions and Factors on developing Parkinson’s Disease: Inferences from a Data-Driven Causal Forest Model
Objective: To investigate the directional influence between cardiovascular factors/interventions and Parkinson’s disease using causal inference based machine learning techniques. Background: Parkinson’s disease (PD) is a…Autoimmune GFAP astrocytopathy as an Etiology of Opsoclonus-Myoclonus-Ataxia Syndrome
Objective: To report a case of opsoclonus-myoclonus-ataxia syndrome (OMAS) due to autoimmune GFAP astrocytopathy. Background: OMAS is associated with brainstem pathology. In adults, common causes…Resolution Dependence of Machine Learning for Differential Diagnosis of Parkinsonian Eye Movements
Objective: To establish the extent to which high temporal resolution is required to differentiate between parkinsonian disease states from eye movements. Background: Previous studies have…Multimodal and Agentic Simulated AI Patients for Bridging the gap in Parkinson Disease Education
Objective: To develop an AI training platform in PD counseling that utilizes real-time NLP processing, multimodal inputs/outputs, and adaptive reinforcement learning supported by immediate feedback…Advancing Hypomimia Assessment in Parkinson’s Disease by Integrating a Continuous Monitoring Device into Clinical Practice
Objective: We aim to establish a robust, continuous method for monitoring hypomimia in Parkinson’s disease (PD), bridging the gap between sporadic clinical evaluations and real-life…Virtual Gait Lab: Assessment of Freezing of Gait in Parkinson’s Disease Using Virtual Reality
Objective: To develop and validate the effectiveness of a "Virtual Gait Lab" system using virtual reality (VR) technology for provoking and evaluating gait disturbances in…Digital Measures for Clinical Trial Endpoints in Huntington’s Disease (MEND-HD): Study Design and Status Update
Objective: To evaluate and establish the analytical validation, reliability, and meaningfulness of digital measures of gait and chorea in early Huntington’s disease (HD). Background: HD…Role of 7-Tesla MRI in assessing clinical symptoms in CSF1R-Related Disorders
Objective: To evaluate utility of 7-tesla magnetic resonance imaging (7T MRI) as a biomarker of CSR1R-Related Disorder (CSF1R-RD). Background: CSF1R-RD is a rapidly progressive neurodegenerative…
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