Effects of Exogenous Melatonin on Sleep and Motor Symptoms in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To evaluate melatonin's efficacy in enhancing sleep and motor symptoms in Parkinson’s disease (PD) through an updated systematic review and meta-analysis. Background: Sleep disturbances…The sphingolipid Lyso-Gb3, a biomarker for the lysosomal storage disorder Fabry Disease, is significantly elevated in blood from patients with Parkinson’s Disease
Objective: To better understand lysosomal dysfunction in Parkinson’s Disease. Background: Lysosomal dysfunction and α-synuclein accumulation play central roles in Parkinson’s Disease. They are interconnected by…Evaluation of the Pharmacodynamic Effects of BIIB122/DNL151 in Participants with LRRK2 mutation-driven Parkinson’s disease (BEACON Study)
Objective: To characterize the biomarker effects of BIIB122/DNL151 in participants with LRRK2 pathogenic mutations diagnosed with Parkinson’s disease (LRRK2-PD). Background: BIIB122/DNL151 is a CNS-penetrant small…Utilization of Phosphorylated Alpha-Synuclein Skin Biopsy Testing in a Movement Disorders Center
Objective: To describe the utilization patterns of skin biopsy for phosphorylated alpha-synuclein (P-syn) aggregation obtained from three sites (posterior cervical, distal thigh, distal leg) and…Parkinson’s Disease and Type 2 Diabetes Severity: a Case-control Biomarker Study
Objective: We used blood-based markers of neuroaxonal damage, inflammation, and glycaemic control to examine whether Type 2 Diabetes (T2D) is linked to a more severe…Broad spectrum local field potential activities as a novel biomarker for adaptive deep brain stimulation
Objective: This study aims to evaluate the wider frequency range (1-200 Hz) LFPs as the novel neural biomarkers for adaptive DBS. In parkinsonism rats, we…Enhancing Parkinson’s Disease Detection Through Chemical and Motor Biomarkers
Objective: To assess the relationship between gait performance and the noninvasive detection of gaseous biomarkers emitted from the skin in denovo persons with Parkinson's disease…Validation of CSF Alpha-synuclein SAA in an Autopsy Cohort with Systemic Assessment of Lewy Pathology Including the Body
Objective: Based on the recent recommendations by international neuropathologists [1], we attempted to evaluate the diagnostic accuracy of cerebrospinal fluid (CSF) alpha-synuclein (α-syn) seeding amplification…Interactions between APOE E4 and idiopathic Parkinson’s disease in age-related hearing loss
Objective: Examine the interaction between APOE E4 and idiopathic Parkinson’s disease (PD) on age-related hearing loss using a validated web-based speech-in-noise assessment. Background: Age is…Aberrations in Voluntary Thought Initiation: Parallels to Motor Freezing in Basal Ganglia Dysfunction
Objective: To explore the neurophysiological basis of impaired volitional thought initiation focusing on dorsal caudate dysfunction, aberrant pallidal-thalamic inhibition, and impaired corticostriatal integration. Background: While…
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