Design, synthesis and pharmacological evaluation of 16-pyridylmethylene derivatives of steroidal oximes as antiparkinsonian agents in MPTP-injected mice.
Objective: The objective of the present study is focused on the design and synthesis of 16-pyridyl methylene derivatives of steroidal oximes and further their pharmacological…Differences in Molecular and Ultrastructural profiles of astroglia and microglia in substantia nigra of two different mice strains in normal aging and experimental Parkinsonism
Objective: To examine whether the variable sensitivity of dopaminergic neurons of the substantia nigra pars compacta -SNpc- in C57BL/6J and CD-1 mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/ MPTP…Impact of sub-acute MPTP exposure on the cerebellum in adult male Balb/c mice
Objective: The objective of the study was to investigate the effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration on the cerebellum of adult male Balb/c mice Background: Parkinson’s…Thymoquinone and Edible Bird Nest: The Secret Ingredients to Protect Against MPTP-induced zebrafish Parkinson’s disease
Objective: Objectives: to create and validate an MPTP neurotoxin-based zebrafish model of Parkinson's disease and explore the therapeutic potential and neuroprotective effects of thymoquinone and…Selenium mitigates ferroptosis-mediated dopaminergic cell death by regulating the Nrf2/GPX4 pathway: Implication for Parkinson’s disease
Objective: The objective of this study is to explore the protective properties of selenium in an in vitro PD model, especially focusing on its underlying…The effect of anti- Parkinson’s disease granules and probiotics on gastrointestinal motility in the mouse model of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine -induced Parkinson’s disease
Objective: To investigate the effect of anti- Parkinson’s disease (anti-PD granules) and probiotics on gastrointestinal motility in the mouse model of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine( MPTP )-induced PD. Background:…Pharmacological Invivo and invitro potential of resveratrol in experimental rat models of Parkinson’s disease
Objective: Aim of study was to elucidate the pharmacological Invivo and invitro effects and mechanisms of action ofRT in experimental models of PD. Background: The…Sub-cellular alterations in MPTP-induced in-vivo and in-vitro systems and Non-MPTP human Parkinsonian skin biopsies: Verifying the sequelae of differential toxicity
Objective: To evaluate the possible temporal hierarchy of sub-cellular organellar degeneration in experimental models of Parkinson’s disease (PD), using MPTP/MPP+ Background: Higher prevalence of PD in…Comparative whole transcriptome analysis of human and mice models of Parkinson’s disease bearing defective glucocerebrosidase activity revealed alteration of expression profile of genes involved in the autophagy
Objective: To identify potential biomarkers of Parkinson's disease (PD) associated with dysfunction of enzyme glucocerebrosidase (GCase) by a comparative whole transcriptome analysis of animal models…Establishing and validating 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced zebrafish model of Parkinson’s disease
Objective: The current study aims to establish a zebrafish model of PD using MPTP neurotoxin and the validation of the MPTP effect through swimming behavior…
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