The Impact of Microgravity and Herpes Simplex Virus 1 on Parkinson’s Neurodegeneration and HERV Expression
Objective: The present abstract aims to investigate the impact of viral infections and microgravity exposure in the context of Parkinson’s disease (PD). Background: PD is…Characterization of the Dnajc13 p.N860S mouse model, a physiological model of alpha-Synuclein overexpression
Objective: To characterize the Dnajc13 p.N860S mouse model of familial Parkinson’s disease Background: DNAJC13/RME-8 is a large, multi-domain molecular co-chaperone that facilitates membrane recycling and…Clinical Features Suggestive of Alpha-Synucleinopathy in Progressive Supranuclear Palsy
Objective: To compare the presence of symptoms suggestive of synucleinopathy between PSP-parkinsonism (PSP-P), Parkinson's disease (PD) and PSP-Richardson syndrome (PSP-RS). Background: Clinical signs with high…Assessment of the impact of the diabetic features hyperglycemia and insulin resistance on fibril induced synucleinopathy
Objective: Investigate the effects of diabetic features on the induction and severity of synucleinopathies such as Parkinson’s disease (PD). Background: Type 2 diabetes (T2D) is…Diagnostic accuracy and clinical correlates of real-time quaking-induced conversion assay on gastric biopsy in early Parkinson’s disease
Objective: To evaluate the utility of the real-time quaking-induced conversion (RT-QuIC) assay in stomach biopsies as a biomarker for early Parkinson’s disease (PD) and to…Characterization of neuronal exosomes purified from plasma of Parkinson’s Disease Chilean patients
Objective: The diagnosis of PD is usually late and has only palliative treatments that seek to slow the progression of motor symptoms. These characteristics make…Moyamoya Disease and the Risk of Parkinson’s Disease
Objective: We aimed to determine whether the risk of Parkinson’s disease (PD) is increased in patients with Moyamoya disease (MMD) and to identify the potential…Neurite Orientation Dispersion and Density Imaging revals reveals white matter microstructural changes in isolated REM sleep behavior disorder
Objective: To characterize white matter microstructural alterations in isolated REM sleep behavior disorder (iRBD) using both conventional diffusion tensor imaging and advanced Neurite Orientation Dispersion…A Randomized, Double-blind Phase 3 Trial of Amlenetug Versus Placebo in Patients with MSA: The MASCOT Trial
Objective: Describe the protocol for a randomized, double-blind phase 3 trial evaluating the efficacy and safety of amlenetug versus placebo in slowing clinical progression in…Correlations of catecholamine metabolites and alpha-synuclein by nigral stimulation in Parkinson’s disease model rat
Objective: We aimed to clarify the effects of substantia nigra (SN) stimulation on catecholamine levels and α-synuclein in PD model rats. Background: Catecholaminergic neurons are…
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