Structural analysis of the basal ganglia using ex vivo 7T MRI can differentiate frontotemporal lobar degeneration with TDP-43 vs tau accumulation.
Objective: Ex vivo 7T MRI can identify macrostructural changes in the basal ganglia that reflect underlying neuropathology, and can be used to differentiate between proteinopathies…Patterns of subthalamic synchronized oscillatory activity associated with parkinsonian subtypes
Objective: To explore whether patterns of synchronized subthalamic oscillatory neurons are involved in generating parkinsonian subtypes. Background: The pathophysiology for parkinsonian subtypes is unclear. Both…Amplifying or suppressing subthalamic beta oscillations in real-time in Parkinson’s disease using evoked interference deep brain stimulation (eiDBS): feasibility in the human
Objective: To assess the feasibility of continuously amplifying or suppressing subthalamic beta oscillations in real-time in Parkinson's disease (PD) patients using a bidirectional, closed-loop brain…Role of the direct subthalamo-cerebellar tract in memory and learning: Implications for the pathophysiology of late-stage Parkinson’s Disease
Objective: To study the role of the recently identified direct subcortical cerebellum basal ganglia (C-BG) network in the pathophysiology of Parkinson’s Disease (PD). Background: Even…Increased alpha power in basal ganglia and thalamus following levodopa administration in a dystonic young adult
Objective: To evaluate effects of acute levodopa administration on frequency content of intracranial local field potentials in a dystonic young adult. Background: Levodopa is the…Automatic assessment of tic expression using selfie-video
Objective: To create an automatic objective measure for quantifying tic expression and modulation in natural behavioral settings. Background: Tourette syndrome (TS) is characterized by the…Evoking Parkinsonism in Mice by a Pharmacological Approach Combined with Targeted Viral-based Manipulations of Neuronal Ensembles
Objective: We implement a pharmacological approach for eliciting dopamine deprivation using transient blockage of dopamine signaling to replicate core parkinsonian motor symptoms. Background: Parkinson’s disease…Dysconnectivity of the Parafascicular Nucleus in Parkinson’s Disease
Objective: The present study aimed to investigate the functional alterations of the parafascicular nucleus (Pf) projections in Parkinson’s disease (PD) patients. Background: Recent animal model…Exome sequencing of 584 Chinese proband with brain calcification
Objective: The aim of this study is to evaluate the diagnostic value of whole exome sequencing in Chinese patients with brain calcification, and to provide exome sequencing-based insights into the genetic…Uremic encephalopathy (UE) mimicking acute bulbar stroke with progression from bradykinesia to choreic movements in a diabetic patient undergoing hemodialysis: A case report
Objective: To present a case of uremic striatopallidal syndrome manifested by both hypo-and hyperkinetic extrapyramidal movements. Background: UE is an uncommon neurologic complication encountered in…
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